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- Primary antibodies
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Product name
Tollip peptide
See all Tollip products (2) ...
Protein description
Synthetic peptide. 16 amino acids near the carboxy terminus of human Tollip. This peptide was used as an immunogen for ab37155 - Tollip antibody.
Properties
Purification notes
60-70% purity.
Biological activity
Blocking the activity of TOLLIP antibody.
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 0.1% BSA, PBS, pH 7.2
Concentration
Concentration information loading...
Research areas
Immunology >> Innate Immunity >> TLR Signaling
Immunology >> Innate Immunity >> Cytokines >> Interleukins
Immunology >> Immunoglobulins >> Receptors
Applications
Show applications key
Our Abpromise guarantee covers the use of ab40023 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking
Application notes
BL: Use at an assay dependent dilution.
This peptide usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37°C.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Protein info
Function
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity.
Sequence similarities
Belongs to the tollip family.
Contains 1 C2 domain.
Contains 1 CUE domain.
Post-translational
modifications
Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products.
Cellular localization
Cytoplasm.
Target information above from: UniProt accessionQ9H0E2
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
References for Tollip peptide (ab40023)
ab40023 has not yet been referenced specifically in any publications.
Publishing research using ab40023? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"