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Topotecan hydrochloride (SK&F 104864)

Product code: ab120388 (formerly Asc-388)

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Overview

Product name

Topotecan hydrochloride (SK&F 104864)

Description

Topoisomerase inhibitor

Alternative names

  • SK&F 104864

Biological description

Topoisomerase I inhibitor. Water-soluble derivative of camptothecin ab120115. Anticancer agent.

Purity

> 98%

General notes

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Properties

Chemical name

(S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride

Molecular Weight

457.91

Chemical structure

Chemical Structure

Molecular formula

C23H23N3O5.HCl

CAS Number

119413-54-6

Solubility

Soluble in water to 100 mM and in DMSO to 100 mM

PubChem identifier

0

Storage instructions

Store at -20°C (desiccating conditions).

Research areas

Biochemicals >> Pharmacology >> Enzymes >> Isomerase >> Topoisomerase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals

References for Topotecan hydrochloride (SK&F 104864) (ab120388)

This product has been referenced in:

  • Mathijssen RH  et al. Pharmacology of topoisomerase I inhibitors irinotecan (CPT-11) and topotecan. Curr Cancer Drug Targets 2:103-23 (2002).Read more (PubMed: 12188913) »
  • Tanizawa A  et al. Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials. J Natl Cancer Inst 86:836-42 (1994).Read more (PubMed: 8182764) »

See all 2 publications for this product

Publishing research using ab120388? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"