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Anti-Transferrin Receptor antibody [RVS10] (Phycoerythrin) (ab25543)

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Overview

  • Product nameAnti-Transferrin Receptor antibody [RVS10] (Phycoerythrin)See all Transferrin Receptor primary antibodies ...
  • Description
    Mouse monoclonal [RVS10] to Transferrin Receptor (Phycoerythrin)
  • ConjugationPhycoerythrin
  • Specificityab25543 recognises Transferrin receptor
  • Tested applicationsFlow Cyt more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein (Human)

Properties

Applications

Our Abpromise guarantee covers the use of ab25543 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
Flow Cyt Flow Cyt: Use 10µl for 106 cells.

Target

  • FunctionCellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
  • Sequence similaritiesBelongs to the peptidase M28 family. M28B subfamily.
    Contains 1 PA (protease associated) domain.
  • Post-translational
    modifications    N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.
    Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).
    Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.
  • Cellular localizationSecreted and Cell membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

    • Target information above from: UniProt accession P02786 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        CD 71 antibodyCD71 antibodyCD71 antibody
        CD71 antigen antibodyOTTHUMP00000208523 antibodyOTTHUMP00000208524 antibodyOTTHUMP00000208525 antibodyp90 antibodysTfR antibodyT9 antibodyTFR 1 antibodyTFR antibodyTFR1 antibodyTFR1_HUMAN antibodyTFRC antibodyTFRC antibodyTR antibodyTransferrin receptor (p90 CD71) antibodyTransferrin Receptor Protein 1 antibodyTransferrin receptor protein 1, serum form antibodyTRFR antibodyTRFR antibody
      see all

    References for Anti-Transferrin Receptor antibody [RVS10] (Phycoerythrin) (ab25543)

    ab25543 has not yet been referenced specifically in any publications.

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