Anti-Transferrin antibody (ab47981)

Overview

• Product nameAnti-Transferrin antibodySee all Transferrin primary antibodies ...
• Description
  Rabbit polyclonal to Transferrin
• Tested applicationsRIA, WB, ELISA, ICC/IF more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Human Transferrin

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
  Constituents: 50% Glycerol, pH 7.5
• Concentration information loading...
• PurityProtein G purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cardiovascular
  • Blood
  • Serum Proteins

  • Cardiovascular
  • Blood
  • Other

Applications

Target

• FunctionTransferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
• Tissue specificityExpressed by the liver and secreted in plasma.
• Involvement in diseaseDefects in TF are the cause of atransferrinemia (ATRAF) [MIM:209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.
• Sequence similaritiesBelongs to the transferrin family.
  Contains 2 transferrin-like domains.
• Cellular localizationSecreted.

Target information above from: UniProt accession P02787 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 7018 Human
  • Entrez Gene: 7018 Human
  • Entrez Gene: 7018 Human
  • Omim: 190000 Human
  • SwissProt: P02787 Human
  • SwissProt: P02787 Human
  • SwissProt: P02787 Human
  • Unigene: 518267 Human

• Alternative names
  Apotransferrin antibodyBeta 1 metal binding globulin antibodyBeta-1 metal-binding globulin antibody

  DKFZp781D0156 antibodyPRO1400 antibodyPRO1557 antibodyPRO2086 antibodySerotransferrin antibodySerotransferrin precursor antibodySiderophilin antibodyTF antibodyTFQTL1 antibodyTransferin antibodyTransferrin antibodyTRFE_HUMAN antibody

  see all

Anti-Transferrin antibody images

• 

  Immunocytochemistry/ Immunofluorescence-Transferrin antibody(ab47981)
  ICC/IF image of ab47981 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab47981, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.