Anti-Transglutaminase 5/TGM5 antibody (ab210772)
Key features and details
- Rabbit polyclonal to Transglutaminase 5/TGM5
- Suitable for: WB, ICC/IF
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Overview
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Product name
Anti-Transglutaminase 5/TGM5 antibody
See all Transglutaminase 5/TGM5 primary antibodies -
Description
Rabbit polyclonal to Transglutaminase 5/TGM5 -
Host species
Rabbit -
Tested applications
Suitable for: WB, ICC/IFmore details -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
Recombinant full length protein corresponding to Human Transglutaminase 5/TGM5 aa 260-720 (C terminal).
Database link: O43548 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab210772 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/2000. Predicted molecular weight: 81 kDa.
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ICC/IF |
1/50 - 1/100.
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Notes |
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WB
1/500 - 1/2000. Predicted molecular weight: 81 kDa. |
ICC/IF
1/50 - 1/100. |
Target
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Function
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes. -
Tissue specificity
Expressed in foreskin keratinocytes. -
Involvement in disease
Defects in TGM5 are a cause of peeling skin syndrome type A (APSS) [MIM:609796]. A non-inflammatory form of peeling skin syndrome, a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis. In APSS patients, skin peeling is strictly limited to the dorsa of the hands and feet, and it is accompanied by accompanied by painless erythema and spontaneous non-scarring healing. Ultrastructural and histological analysis shows a level of blistering high in the epidermis at the stratum granulosum-stratum corneum junction. -
Sequence similarities
Belongs to the transglutaminase superfamily. Transglutaminase family. -
Cellular localization
Cytoplasm. Associated with intermediate filaments. - Information by UniProt
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Database links
- Entrez Gene: 9333 Human
- Entrez Gene: 74176 Mouse
- Entrez Gene: 691929 Rat
- Omim: 603805 Human
- SwissProt: O43548 Human
- SwissProt: Q3V1F9 Mouse
- SwissProt: Q9D7I9 Mouse
- Unigene: 129719 Human
see all -
Alternative names
- Protein glutamine gamma glutamyltransferase 5 antibody
- Protein-glutamine gamma-glutamyltransferase 5 antibody
- PSS2 antibody
see all
Images
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All lanes : Anti-Transglutaminase 5/TGM5 antibody (ab210772) at 1/500 dilution
Lane 1 : Mouse liver extract
Lane 2 : Mouse heart extract
Lane 3 : Rat liver extract
Lane 4 : Rat heart extract
Predicted band size: 81 kDa -
Immunofluorescent analysis of U2OS cells labeling Transglutaminase 5/TGM5 with ab210772 at 1/50 dilution (green). Blue: DAPI for nuclear staining.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab210772 has not yet been referenced specifically in any publications.