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Overview

  • Product nameAnti-Transglutaminase 5 antibodySee all Transglutaminase 5 primary antibodies ...
  • Description
    Rabbit polyclonal to Transglutaminase 5
  • SpecificityThis antibody is specific to Transglutaminase 5 protein from keratinocyte cells.
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    A 15 residue synthetic peptide derived from a domain specific for Transglutaminase 5 protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab26992 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/200 - 1/1000. Predicted molecular weight: 80 kDa.

Target

  • FunctionCatalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.
  • Tissue specificityExpressed in foreskin keratinocytes.
  • Involvement in diseaseDefects in TGM5 are a cause of peeling skin syndrome type A (APSS) [MIM:609796]. A non-inflammatory form of peeling skin syndrome, a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis. In APSS patients, skin peeling is strictly limited to the dorsa of the hands and feet, and it is accompanied by accompanied by painless erythema and spontaneous non-scarring healing. Ultrastructural and histological analysis shows a level of blistering high in the epidermis at the stratum granulosum-stratum corneum junction.
  • Sequence similaritiesBelongs to the transglutaminase superfamily. Transglutaminase family.
  • Cellular localizationCytoplasm. Associated with intermediate filaments.

    • Target information above from: UniProt accession O43548 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    see all
  • Alternative names
      Protein glutamine gamma glutamyltransferase 5 antibodyProtein-glutamine gamma-glutamyltransferase 5 antibodyTG(X) antibody
      TGase 5 antibodyTGase X antibodyTGase-5 antibodyTGase5 antibodyTGM5 antibodyTGM5_HUMAN antibodyTGMX antibodyTGX antibodyTransglutaminase X antibodyTransglutaminase-5 antibody
    see all

References for Anti-Transglutaminase 5 antibody (ab26992)

This product has been referenced in:
  • Zhang Z  et al. Transglutaminase-1 regulates renal epithelial cell proliferation through activation of Stat-3. J Biol Chem 284:3345-53 (2009). WB ; Mouse . Read more (PubMed: 19049964) »

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Please see technical questionnaire and image attached provided by the customer regarding technical issue with cat#: AB26992, Description: Transglutaminase 5 polyclonal antibody, Lot #: GR37636.



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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"