Overview

  • Product nameAnti-Transglutaminase 5 antibody
    See all Transglutaminase 5 primary antibodies
  • Description
    Rabbit polyclonal to Transglutaminase 5
  • Tested applicationsWB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide: LGVLKPQHQA SIILETVPFK SGQRQIQANM RSNKFKDIKG YRNVYVDFAL , corresponding to C terminal amino acids 672-721 of Human Transglutaminase 5, (NP_963925).

  • Positive control
    • HeLa cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab80907 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 37, 42, 80 kDa (predicted molecular weight: 80 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay 1/12500.

Target

  • FunctionCatalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.
  • Tissue specificityExpressed in foreskin keratinocytes.
  • Involvement in diseaseDefects in TGM5 are a cause of peeling skin syndrome type A (APSS) [MIM:609796]. A non-inflammatory form of peeling skin syndrome, a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis. In APSS patients, skin peeling is strictly limited to the dorsa of the hands and feet, and it is accompanied by accompanied by painless erythema and spontaneous non-scarring healing. Ultrastructural and histological analysis shows a level of blistering high in the epidermis at the stratum granulosum-stratum corneum junction.
  • Sequence similaritiesBelongs to the transglutaminase superfamily. Transglutaminase family.
  • Cellular localizationCytoplasm. Associated with intermediate filaments.
  • Information by UniProt
  • Database links
  • Alternative names
    • Protein glutamine gamma glutamyltransferase 5 antibody
    • Protein-glutamine gamma-glutamyltransferase 5 antibody
    • TG(X) antibody
    • TGase 5 antibody
    • TGase X antibody
    • TGase-5 antibody
    • TGase5 antibody
    • Tgm5 antibody
    • TGM5_HUMAN antibody
    • TGMX antibody
    • TGX antibody
    • Transglutaminase X antibody
    • Transglutaminase-5 antibody
    see all

Anti-Transglutaminase 5 antibody images

  • Anti-Transglutaminase 5 antibody (ab80907) at 1 µg/ml + HeLa cell lysate

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 80 kDa
    Observed band size : 80 kDa
    Additional bands at : 37 kDa,42 kDa. We are unsure as to the identity of these extra bands.

References for Anti-Transglutaminase 5 antibody (ab80907)

ab80907 has not yet been referenced specifically in any publications.

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