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Overview

  • Product nameAnti-Transglutaminase 5 antibodySee all Transglutaminase 5 primary antibodies ...
  • Description
    Rabbit polyclonal to Transglutaminase 5
  • Tested applicationsWB, ELISA more details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Cow, Dog
  • Immunogen

    Synthetic peptide: LGVLKPQHQA SIILETVPFK SGQRQIQANM RSNKFKDIKG YRNVYVDFAL , corresponding to C terminal amino acids 672-721 of Human Transglutaminase 5, (NP_963925).

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive controlHeLa cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab80907 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
ELISA
  • Application notesELISA titre using peptide based assay 1/12500.
    WB: Use at a concentration of 1 µg/ml. Detects a band of approximately 37, 42 and 80 kDa (predicted molecular weight: 80 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionCatalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.
    • Tissue specificityExpressed in foreskin keratinocytes.
    • Involvement in diseaseDefects in TGM5 are a cause of peeling skin syndrome type A (APSS) [MIM:609796]. A non-inflammatory form of peeling skin syndrome, a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis. In APSS patients, skin peeling is strictly limited to the dorsa of the hands and feet, and it is accompanied by accompanied by painless erythema and spontaneous non-scarring healing. Ultrastructural and histological analysis shows a level of blistering high in the epidermis at the stratum granulosum-stratum corneum junction.
    • Sequence similaritiesBelongs to the transglutaminase superfamily. Transglutaminase family.
    • Cellular localizationCytoplasm. Associated with intermediate filaments.

      • Target information above from: UniProt accession O43548 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      see all
    • Alternative names
        Protein glutamine gamma glutamyltransferase 5 antibodyProtein-glutamine gamma-glutamyltransferase 5 antibodyTG(X) antibody
        TGase 5 antibodyTGase X antibodyTGase-5 antibodyTGase5 antibodyTgm5 antibodyTGM5_HUMAN antibodyTGMX antibodyTGX antibodyTransglutaminase X antibodyTransglutaminase-5 antibody
      see all

    Anti-Transglutaminase 5 antibody images

    • Western blot - Transglutaminase 5 antibody (ab80907)
      Western blot - Transglutaminase 5 antibody (ab80907)
      Anti-Transglutaminase 5 antibody (ab80907) at 1 µg/ml + HeLa cell lysate

      Secondary
      HRP conjugated anti-Rabbit IgG at 1/50000 dilution

      Predicted band size : 80 kDa
      Observed band size : 80 kDa
      Additional bands at : 37 kDa,42 kDa. We are unsure as to the identity of these extra bands.

    References for Anti-Transglutaminase 5 antibody (ab80907)

    ab80907 has not yet been referenced specifically in any publications.

    Publishing research using ab80907 ? Please let us know so that we can cite the reference in this datasheet

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