Overview

  • Product name
    Triamterene
  • Description
    Epithelial Na+ channel blocker
  • Biological description
    Epithelial Na+ channel blocker (IC50 = 4.5 μM). Inhibits Na+ reabsorption in the late distal convoluted tubule and collecting tubule. Inhibits K+ excretion. Shows diuretic and antihypertensive effects in vivo. Orally active.

Properties

  • Chemical name
    6-Phenylpteridine-2,4,7-triamine
  • Molecular weight
    253.26
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C12H11N7
  • CAS Number
    396-01-0
  • PubChem identifier
    5546
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 75 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1=CC=C(C=C1)C2=NC3=C(N=C2N)N=C(N=C3N)N
  • Source

    Synthetic

  • Research areas

    References for Triamterene (ab145755)

    This product has been referenced in:
    • Deye GA  et al. Use of a rhesus Plasmodium cynomolgi model to screen for anti-hypnozoite activity of pharmaceutical substances. Am J Trop Med Hyg 86:931-5 (2012). Read more (PubMed: 22665596) »
    • Melcescu E  et al. 11Beta-hydroxylase deficiency and other syndromes of mineralocorticoid excess as a rare cause of endocrine hypertension. Horm Metab Res 44:867-78 (2012). Read more (PubMed: 22932914) »
    • Artunc F  et al. Responses to diuretic treatment in gene-targeted mice lacking serum- and glucocorticoid-inducible kinase 1. Kidney Blood Press Res 32:119-27 (2009). Read more (PubMed: 19401625) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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