Epithelial Na+ channel blocker (IC50 = 4.5 μM). Inhibits Na+ reabsorption in the late distal convoluted tubule and collecting tubule. Inhibits K+ excretion. Shows diuretic and antihypertensive effects in vivo. Orally active.
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in DMSO to 75 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Deye GA et al. Use of a rhesus Plasmodium cynomolgi model to screen for anti-hypnozoite activity of pharmaceutical substances. Am J Trop Med Hyg86:931-5 (2012).
Read more (PubMed: 22665596) »
Melcescu E et al. 11Beta-hydroxylase deficiency and other syndromes of mineralocorticoid excess as a rare cause of endocrine hypertension. Horm Metab Res44:867-78 (2012).
Read more (PubMed: 22932914) »
Artunc F et al. Responses to diuretic treatment in gene-targeted mice lacking serum- and glucocorticoid-inducible kinase 1. Kidney Blood Press Res32:119-27 (2009).
Read more (PubMed: 19401625) »