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Anti-TrkB antibody (ab43079)

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Overview

Product name

Anti-TrkB antibody
See all TrkB products (23) ...

Description

Rabbit polyclonal to TrkB

Specificity

From experiments using similar antisera, it is anticipated that the reagent will block TrkB receptor binding of corresponding Nerve Growth factor ligand.

Tested applications

ELISA, IHC-Frmore details

Cross reactivity

Reacts with

Mouse, Rat

Immunogen

Extracellular domain of Mouse TrkB.

Positive control

Rat peripheral sensory ganglia.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Cancer >> Oncoproteins/suppressors >> Oncoproteins >> Growth factor receptors
Neuroscience >> Neurology process >> Growth and Development >> Neurotrophins

  • Immunohistochemistry - TrkB antibody (ab43079)Immunohistochemistry - TrkB antibody (ab43079) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab43079 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

Is unsuitable for or WB.

Target

Function

Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.

Tissue specificity

Isoform TrkB is widely expressed, mainly in the nervous tissue. In the CNS, expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophtalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is expressed in multiple tissues, mainly in brain, pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in brain.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 2 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.
Contains 1 protein kinase domain.

Post-translational
modifications

Ligand-mediated auto-phosphorylation.

Cellular localization

Membrane.

Target information above from: UniProt accessionQ16620 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • AI848316 antibody
  • BDNF tropomyosine receptor kinase B antibody
  • BDNF/NT 3 growth factors receptor antibody
  • BDNF/NT-3 growth factors receptor antibody
  • Brain derived neurotrophic factor receptor antibody
  • C030027L06Rik antibody
  • EC 2.7.10.1 antibody
  • GP145 TrkB antibody
  • GP145-TrkB antibody
  • GP145-TrkB/GP95-TrkB antibody
  • GP95 TrkB antibody
  • GP95-TrkB antibody
  • neurotrophic tyrosine kinase receptor type 2 antibody
  • neurotrophic tyrosine kinase receptor type 2 antibody
  • Neurotrophin receptor tyrosine kinase type 2 antibody
  • NTRK 2 antibody
  • NTRK2 antibody
  • NTRK2 antibody
  • NTRK2_HUMAN antibody
  • Obesity, hyperphagia, and developmental delay, included antibody
  • RATTRKB1 antibody
  • Tkrb antibody
  • Trk B antibody
  • Trk-B antibody
  • TRKB antibody
  • TrkB tyrosine kinase antibody
  • TRKB1 antibody
  • tyrosine kinase receptor B antibody
  • Tyrosine Receptor Kinase B antibody
  • Tyrosine Receptor Kinase B antibody
see all

Database links

Anti-TrkB antibody images:

  Immunohistochemistry - TrkB antibody (ab43079)

Immunohistochemistry - TrkB antibody (ab43079)

The cryostat section of the rat spinal cord was incubated in rabbit polyclonal antibodies to the extracellular domain of mouse TrkB at the dilution of 1/3000 overnight followed with a biotinylated secondary antibodies and ABC kit. The section was developed in diaminobenzidine solution and enhanced in the presence of nickel sulphate. Nerve fibres in the ventral horn are stained.

References for Anti-TrkB antibody (ab43079)

ab43079 has not yet been referenced specifically in any publications.

Publishing research using ab43079? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"