Anti-TIPE2 antibody (ab110389)
Key features and details
- Rabbit polyclonal to TIPE2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-TIPE2 antibody
See all TIPE2 primary antibodies -
Description
Rabbit polyclonal to TIPE2 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide corresponding to Human TIPE2 (internal sequence).
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Positive control
- WB: Extracts from HuvEc cells.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol, 0.88% Sodium chloride -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab110389 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Predicted molecular weight: 21 kDa.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 21 kDa. |
Target
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Function
Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis. -
Sequence similarities
Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily. -
Domain
The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding. - Information by UniProt
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Database links
- Entrez Gene: 79626 Human
- Entrez Gene: 69769 Mouse
- Entrez Gene: 310663 Rat
- Omim: 612112 Human
- SwissProt: Q6P589 Human
- SwissProt: Q9D8Y7 Mouse
- SwissProt: Q6AYJ8 Rat
- Unigene: 709522 Human
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Alternative names
- AW610835 antibody
- FLJ23467 antibody
- Inflammation factor 20 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (10)
ab110389 has been referenced in 10 publications.
- Gao K et al. Down-regulation of anti-inflammatory TIPE2 may aggravate adenoidal hypertrophy in children. FEBS Open Bio 10:761-766 (2020). PubMed: 32100476
- Zhao LL TIPE2 suppresses progression and tumorigenesis of the oral tongue squamous cell carcinoma by regulating FoxP3+ regulatory T cells. J Bioenerg Biomembr 52:279-289 (2020). PubMed: 32594290
- Liu Y et al. TIPE2 inhibits the migration and invasion of endometrial cells by targeting ß-catenin to reverse epithelial-mesenchymal transition. Hum Reprod 35:1377-1390 (2020). PubMed: 32469403
- Huang LQ et al. Immune Negative Regulator TIPE2 Inhibits Cervical Squamous Cancer Progression Through Erk1/2 Signaling. Open Life Sci 14:528-536 (2019). PubMed: 33817189
- Bordoloi D et al. TIPE2 Induced the Proliferation, Survival, and Migration of Lung Cancer Cells Through Modulation of Akt/mTOR/NF-?B Signaling Cascade. Biomolecules 9:N/A (2019). PubMed: 31817720
- Wang Q et al. TIPE2 Suppresses Pseudomonas aeruginosa Keratitis by Inhibiting NF-?B Signaling and the Infiltration of Inflammatory Cells. J Infect Dis 220:1008-1018 (2019). PubMed: 31067300
- Zhu L et al. TIPE2 suppresses progression and tumorigenesis of esophageal carcinoma via inhibition of the Wnt/ß-catenin pathway. J Transl Med 16:7 (2018). PubMed: 29343267
- Jiang Y et al. TIPE2 governs macrophage polarization via negative regulation of mTORC1. Mol Med Rep 17:952-960 (2018). PubMed: 29115630
- Jiang J et al. Stable silencing of TIPE2 reduced the Poly I:C-induced apoptosis in THP-1 cells. Mol Med Rep 16:6313-6319 (2017). PubMed: 28849057
- Shi C et al. Tumor necrosis factor-a-induced protein-8 like 2 regulates lipopolysaccharide-induced rat rheumatoid arthritis immune responses and is associated with Rac activation and interferon regulatory factor 3 phosphorylation. Mol Med Rep 16:6346-6353 (2017). PubMed: 28849230