Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Reassurance, Refunds & Replacements
If your product does not perform as described on this datasheet, we will refund or replace your product...
Read our guarantee »Overview
Product name
Tunicamycin from Streptomyces sp
Description
Antibiotic. Protein glycosylation inhibitor
Biological description
Nucleoside antibiotic that inhibits protein glycosylation. Inhibits GlcNAc phosphotransferase (GPT) and inhibits the transfer of N-acetylglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi, and viruses.
Purity
> 99%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
This compound is a mixture of the homologs of tunicamycin: A, B, C and D which vary in the carbon chain length (n=8 to 11)
Country restrictions and/or license requirements may apply. Please contact customer services for further details.
Properties
Chemical name
Molecular Weight
844.95
Chemical structure
Molecular formula
C39H64N4O16(for tunicamycin C, n=10)
CAS Number
11089-65-9
Solubility
Soluble in DMSO to 50 mM
Storage instructions
Store at +4°C (desiccating conditions). Do not freeze.
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Transferase
Biochemicals >> Chemical Type >> Antibiotic
Biochemicals >> Chemical Type >> Biochemicals
References for Tunicamycin from Streptomyces sp (ab120296)
This product has been referenced in:
- Price NP & Tsvetanova B Biosynthesis of the tunicamycins: a review. J Antibiot (Tokyo) 60:485-91 (2007).Read more (PubMed: 17827659) »
- Duksin D & Mahoney WC Relationship of the structure and biological activity of the natural homologues of tunicamycin. J Biol Chem 257:3105-9 (1982).Read more (PubMed: 7061468) »
See all 2 publications for this product
Publishing research using ab120296? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"