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Product name
U0126
Description
Selective MKK inhibitor
Biological description
Selective non-competitive inhibitor of MAP kinase kinase (MKK). Inhibits MKK1, MKK2 (IC50 values of 0.07 and 0.06 μM respectively) and MKK5 with little or no effect on a wide range of other kinases. Centrally active following systemic administration in vivo.
Purity
> 98%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene
Molecular Weight
380.49
Chemical structure
Molecular formula
C18H16N6S2
CAS Number
109511-58-2
Solubility
Soluble in DMSO to 100 mM
Storage instructions
Store at +4°C (desiccating conditions). Do not freeze.
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> MKK >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for U0126 (ab120241)
This product has been referenced in:
- Bain J et al. The selectivity of protein kinase inhibitors: a further update. Biochem J 408:297-315 (2007).Read more (PubMed: 17850214) »
- Favata MF et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273:18623-32 (1998).Read more (PubMed: 9660836) »
See all 3 publications for this product
Publishing research using ab120241? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"