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Product Name
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U1A peptide
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Product type
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Proteins and Peptides
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Peptide
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Synthetic peptide derived from within residues 150 - 250 of Human U1A.This peptide was used as an immunogen for ab40689 - U1A antibody.
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Research areas
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Chromatin and Nuclear Signaling >> DNA / RNA >> RNA Processing >> Splicing
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Relevance
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U1A binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) it may be involved in coupled pre-mRNA splicing and polyadenylation process.
It belongs to the spliceosome where it is associated with snRNP U1. It interacts with SFPQ (referenced from swissprot).
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Storage buffer
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Preservative: None
Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this U1A peptide is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to U1A
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