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Western blot - UBE2V1 antibody (ab88680)
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Western blot - UBE2V1 antibody (ab88680)
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Product Name
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UBE2V1 antibody
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See all UBE2V1 antibodies (5)...
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Product type
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Primary antibodies
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Description
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Mouse polyclonal to UBE2V1
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Immunogen
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Full length human UBE2V1 (NP_071887.1).
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Reacts with
(species key)
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Hu
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Tested applications
(see key)
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
WB: Use at a concentration of 1 µg/ml. Predicted molecular weight: 11 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Human kidney tissue lysate and UBE2V1 transfected 293T cell lysate.
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Cellular localization
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Nucleus. Excluded from the nucleolus.
(CROC1B/Kua-UBE2V1 transcript is cytoplasmic).
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Research areas
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Chromatin and Nuclear Signaling >> Cell cycle >> Ubiquitin ligases
Chromatin and Nuclear Signaling >> Transcription >> Other factors
Cell Biology >> Cell Cycle >> Cell differentiation
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> NFkB Pathway
Cell Biology >> Proteolysis / Ubiquitin >> Proteasome / Ubiquitin >> Ubiquitin E2s and E3s >> Ubiquitin E2 Enzymes
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Relevance
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Ubiquitin-conjugating E2 enzyme (UBE2V1) is located in the nucleus and can cause transcriptional activation of the Human FOS proto-oncogene. Multiple alternatively spliced transcripts encoding different isoforms have been described for this gene. The UBE2V1/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2.
Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Protein A purified
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Storage buffer
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Preservative: None
Constituents: 1X PBS, pH 7.2
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this UBE2V1 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for UBE2V1 antibody images, references, products related to ab88680 and other tools.
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UBE2V1 antibody images:
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 Western blot - UBE2V1 antibody (ab88680)
All lanes : UBE2V1 antibody (ab88680) at 1 µg/ml
Lane 1 : UBE2V1 transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Predicted band size : 11 kDa
Observed band size : 11 kDa
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Search PubMed (MEDLINE) for references to UBE2V1
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UBE2V1 antibody - more information
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Customer reviews (feedback) regarding UBE2V1 antibody |
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UBE2V1 antibody - related products:
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