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Overview

  • Product nameUBP141
  • Description
    GluN2D (formerly NR2D) antagonist, with some subunit selectivity
  • Biological descriptionGluN2D (formerly NR2D) antagonist, displaying modest GluN2 (NR2) subunit selectivity. Shows 7-fold selectivity for GluN2D (NR2D)-containing NMDA receptors vs GluN2B (NR2B) and 5-fold selectivity over GluN2A (NR2A ) but does not discriminate between GluN2C (NR2C) and GluN2D (NR2D). Ki values are 22, 17.2, 5.24 and 2.36 μM for NR1/2A, NR1/2B, NR1/2C and NR1/2D receptors respectively.
  • Purity> 98%

    • Properties

  • Chemical name(2R*,3S*)-1-(Phenanthrenyl-3-carbonyl)piperazine-2,3-dicarboxylic acid
  • Molecular Weight378.38
  • Chemical structureChemical Structure
  • Molecular formulaC21H18N2O5
  • CAS Number344768-30-5
  • Storage instructionsStore at +4°C (desiccating conditions).
  • Solubility overviewSoluble in 2 eq. NaOH to 50 mM (with warming)
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • SMILESO=C(c1cc2c3ccccc3ccc2cc1)N4CCNC(C(=O)O)C4C(=O)O
  • Source

    Synthetic

  • Research Areas

    • References for UBP141 (ab120193)

    This product has been referenced in:
    • Costa BM  et al. N-methyl-D-aspartate (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse. J Pharmacol Exp Ther 331:618-26 (2009). Read more (PubMed: 19684252) »
    • Brothwell SL  et al. NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones. J Physiol 586:739-50 (2008). Read more (PubMed: 18033813) »
    • Morley RM  et al. Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J Med Chem 48:2627-37 (2005). Read more (PubMed: 15801853) »

    See all 5 Publications for this product

    Publishing research using ab120193 ? Please let us know so that we can cite the reference in this datasheet

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"