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Overview

  • Product nameUBR1 peptideSee all UBR1 proteins and peptides ...
  • Protein descriptionSynthetic peptide derived from within residues 250 - 350 of Human UBR1.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab42420 - UBR1 antibody.
  • Protein length1749 amino acids

    • Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferInformation available upon request.
  • Concentration information loading...
  • Research Areas

    • Applications

  • Application notesThis peptide can be used with studies using ab42420.

    • Protein info

    • Alternative names
        E3 ubiquitin-protein ligase UBR1JBSN-recognin-1
        ubiquitin protein ligase E3 component n-recognin 1Ubiquitin-protein ligase E3-alpha-1Ubiquitin-protein ligase E3-alpha-IUBR1UBR1_HUMAN
      see all
  • FunctionE3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
  • Tissue specificityBroadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level).
  • PathwayProtein modification; protein ubiquitination.
  • Involvement in diseaseDefects in UBR1 are a cause of Johanson-Blizzard syndrome (JBS) [MIM:243800]. This disorder includes congenital exocrine pancreatic insufficiency, multiple malformations such as nasal wing aplasia, and frequent mental retardation. Pancreas of individuals with JBS do not express UBR1 and show intrauterine-onset destructive pancreatitis.
  • Sequence similaritiesBelongs to the UBR1 family.
    Contains 1 RING-type zinc finger.
    Contains 1 UBR-type zinc finger.
  • Developmental stageExpressed in fetal pancreas.
  • DomainThe RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif.
  • Post-translational
    modifications    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationCytoplasm > cytosol.

    • Target information above from: UniProt accession Q8IWV7 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for UBR1 peptide (ab42419)

    ab42419 has not yet been referenced specifically in any publications.

    Publishing research using ab42419 ? Please let us know so that we can cite the reference in this datasheet

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