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Products:Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> DNA Damage Response >> Other
Overview
Product name
Anti-MMS2 antibody
See all MMS2 products (3) ...
Description
Goat polyclonal to MMS2
Tested applications
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Rat
Immunogen
Synthetic peptide: AVSTGVKVPRNF, corresponding to N terminal amino acids 2-13 of Human UEV2.
AVSTGVKVPR NF-C
Positive control
Human Brain lysate.
General notes
Principal Names – UBE2V2; ubiquitin-conjugating enzyme E2 variant 2; MMS2; UEV2; EDPF1; UEV-2; DDVIT1; EDAF-1; EDPF-1; DDVit-1; 1 alpha,25-dihydroxyvitamin D3-inducible; enterocyte differentiation promoting factor; methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of Official Gene Symbol - UBE2V2.
GenBank Accession Number – NP_003341.
LocusLink ID - 7336 (human); 70620 (mouse).
Gene Ontology terms - cell proliferation; polyubiquitination; regulation of DNA repair; regulation of cell cycle; ubiquitin conjugating enzyme.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, 0.5mg/ml Tris, pH 7.3
Concentration
Concentration information loading...
Purity
IgG fraction
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> Ubiquitin & Ubiquitin Like Modifiers >> E2 Ubiquitin Conjugating Enzymes
Epigenetics and Nuclear Signaling >> Cell cycle >> Ubiquitin ligases
Cell Biology >> Proteolysis / Ubiquitin >> Proteasome / Ubiquitin >> Ubiquitin E2s and E3s >> RING Finger E3 Ligase
Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> DNA Damage Response >> Other
Applications
Show applications key
Our Abpromise guarantee covers the use of ab2513 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
Application notes
Western Blot – Approx 20kDa band seen in Human Brain lysate. Recommended for use at 0.2-1.0ug/ml.
Target
Function
Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
Tissue specificity
Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues.
Sequence similarities
Belongs to the ubiquitin-conjugating enzyme family.
Target information above from: UniProt accessionQ15819
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- 1 alpha 25 dihydroxyvitamin D3 inducible antibody
- 1 alpha 25-dihydroxyvitamin D3 inducible antibody
- DDVit 1 antibody
see all
Database links
- Entrez Gene: 7336 Human
- Entrez Gene: 100503412 Mouse
- Entrez Gene: 70620 Mouse
- Entrez Gene: 287927 Rat
- Omim: 603001 Human
- SwissProt: Q15819 Human
- SwissProt: Q9D2M8 Mouse
- SwissProt: Q7M767 Rat
see all
References for Anti-MMS2 antibody (ab2513)
ab2513 has not yet been referenced specifically in any publications.
Publishing research using ab2513? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"