Anti-UHRF1 antibody (ab93419)

Overview

• Product nameAnti-UHRF1 antibodySee all UHRF1 primary antibodies ...
• Description
  Rabbit polyclonal to UHRF1
• Tested applicationsWB, ELISA more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  KLH conjugated synthetic peptide selected from the central region of Human UHRF1.

• Positive controlHeLa cell lysate

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesPurified through a protein A column, followed by peptide affinity purification.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Epigenetics and Nuclear Signaling
  • Chromatin Binding Proteins
  • Methyl Lysine

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Domain Families
  • Zinc Finger

Applications

Target

• FunctionPutative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability.
• Tissue specificityExpressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer.
• PathwayProtein modification; protein ubiquitination.
• Sequence similaritiesContains 1 PHD-type zinc finger.
  Contains 2 RING-type zinc fingers.
  Contains 1 ubiquitin-like domain.
  Contains 1 YDG domain.
• Developmental stageExpressed in fetal thymus, liver and kidney.
• DomainThe RING finger is required for ubiquitin ligase activity.
  The YDG domain mediates the interaction with histone H3.
• Post-translational
  modificationsPhosphorylated on serine residues. Phosphorylation may enhance DNA-binding activity.
  Ubiquitinated; which leads to proteasomal degradation. Polyubiquitination may be stimulated by DNA damage.
• Cellular localizationNucleus.

Target information above from: UniProt accession Q96T88 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 29128 Human
  • Omim: 607990 Human
  • SwissProt: Q96T88 Human
  • Unigene: 108106 Human

• Alternative names
  Ac2-121 antibodyAL022808 antibodyE3 ubiquitin-protein ligase UHRF1 antibody

  EC 6.3.2.- antibodyFLJ21925 antibodyhNP95 antibodyhUHRF1 antibodyHuNp95 antibodyICBP90 antibodyInverted CCAAT box binding protein of 90 kDa antibodyInverted CCAAT box binding protein, 90-kD antibodyInverted CCAAT box-binding protein of 90 kDa antibodyLiver regeneration-related protein LRRG126 antibodyMGC138707 antibodyNP95 antibodyNuclear phosphoprotein, 95-KD antibodyNuclear protein 95 antibodyNuclear zinc finger protein Np95 antibodyRING finger protein 106 antibodyRNF106 antibodyTranscription factor ICBP90 antibodyUbiquitin like containing PHD and RING finger domains protein 1 antibodyUbiquitin like PHD and RING finger domain containing protein 1 antibodyUbiquitin-like PHD and RING finger domain-containing protein 1 antibodyUbiquitin-like protein containing PHD and RING finger domains 1 antibodyUbiquitin-like with PHD and ring finger domains 1 antibodyUbiquitin-like, containing PHD and RING finger domains, 1 antibodyUbiquitin-like-containing PHD and RING finger domains protein 1 antibodyUHRF1 antibodyUHRF1_HUMAN antibody

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Anti-UHRF1 antibody images

• 

  Western blot - UHRF1 antibody (ab93419)
  Anti-UHRF1 antibody (ab93419) at 1/100 dilution + HeLa cell lysate at 35 µg
  
  Predicted band size : 90 kDa