Anti-UPP2 antibody (ab108049)

Overview

• Product nameAnti-UPP2 antibodySee all UPP2 primary antibodies ...
• Description
  Rabbit polyclonal to UPP2
• Tested applicationsWB, IHC-P more details
• Species reactivity
  Reacts with: Mouse, Human
  
• Immunogen

  Synthetic peptide between C terminal amino acids 217-244 of Human UPP2 (NP_775491.1), conjugated to KLH.

• Positive controlMouse heart tissue lysates; Human kidney carcinoma

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesPurified through a protein A column, followed by peptide affinity purification.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Nucleotide metabolism
  • Purine and pyrimidine synthesis

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Energy Metabolism

  • Signal Transduction
  • Metabolism
  • Energy Metabolism

  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA / Nucleotides

Applications

Target

• FunctionCatalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates.
• Tissue specificityPredominantly expressed in kidney.
• PathwayPyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.
• Sequence similaritiesBelongs to the PNP/UDP phosphorylase family.

Target information above from: UniProt accession O95045 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 151531 Human
  • Entrez Gene: 151531 Human
  • Entrez Gene: 76654 Mouse
  • SwissProt: O95045 Human
  • SwissProt: O95045 Human
  • SwissProt: Q8CGR7 Mouse
  • Unigene: 128427 Human
  • Unigene: 200370 Mouse

  • Unigene: 378432 Mouse
  • Unigene: 437094 Mouse

  see all

• Alternative names
  Liver specific uridine phosphorylase antibodyUDRPASE2 antibodyUP2 antibody

  UPase 2 antibodyUPASE2 antibodyUPP 2 antibodyUPP2 antibodyUPP2_HUMAN antibodyUrdPase 2 antibodyUridine phosphorylase 2 antibody

  see all

Anti-UPP2 antibody images

• 

  Western blot - UPP2 antibody (ab108049)
  Anti-UPP2 antibody (ab108049) at 1/100 dilution + Mouse heart tissue lysates at 35 µg
  
  Predicted band size : 36 kDa
  
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - UPP2 antibody (ab108049)
  ab108049, at a 1/50 dilution, staining UPP2 in formalin fixed, paraffin embedded Human kidney carcinoma by Immunohistochemistry, followed by peroxidase conjugation of the secondary antibody and DAB staining.