![Western blot - testtesttest antibody [1H9DE5DG5BC8] (ab110255) image](#testtesttest-Primary-antibodies-ab110255-1.jpg)
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Product name
Anti-UQCRQ antibody [1H9DE5DG5BC8]
See all UQCRQ products (2) ...
Description
Mouse monoclonal [1H9DE5DG5BC8] to UQCRQ
Tested applications
Cross reactivity
Reacts with
Mouse, Rat, Cow, Human
Immunogen
Bovine Complex III subunit 8 (UQCRQ)
Positive control
Human, Cow, Rat or Mouse heart mitochondrial lysate
Properties
Form
Liquid
Storage instructions
Store at +4°C. Do not freeze.
Storage buffer
Preservative: 0.02% Sodium azide
Constituent: HBS
Concentration
Concentration information loading...
Purification notes
Near homogeneity as judged by SDS-PAGE. Produced in vitro using hybridomas grown in serum-free medium, and then purified by biochemical fractionation.
Clonality
Monoclonal
Clone number
1H9DE5DG5BC8
Isotype
IgG2a
Light chain type
kappa
Research areas
Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Mitochondrial Metabolism >> Oxidative phosphorylation >> Complex III
Metabolism >> Pathways and Processes >> Redox metabolism >> Antioxidants
Metabolism >> Pathways and Processes >> Redox metabolism >> Oxidative stress
Metabolism >> Pathways and Processes >> Mitochondrial Metabolism >> Mitochondrial markers
Cell Biology >> Other Antibodies >> Oxidative Stress
Signal Transduction >> Metabolism >> Mitochondrial
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Western blot - testtesttest antibody [1H9DE5DG5BC8] (ab110255)
![Western blot - testtesttest antibody [1H9DE5DG5BC8] (ab110255) image](/ps/datasheet/images/110/ab110255/testtesttest-Primary-antibodies-ab110255-1.jpg)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab110255 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/1. Predicted molecular weight: 6 kDa.
Target
Function
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone.
Involvement in disease
Defects in UQCRQ are a cause of mitochondrial complex III deficiency (MT-C3D) [MIM:124000]. A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance.
Sequence similarities
Belongs to the UQCRQ/QCR8 family.
Cellular localization
Mitochondrion inner membrane.
Target information above from: UniProt accessionO14949
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Complex III subunit 8 antibody
- Complex III subunit VIII antibody
- Cytochrome b-c1 complex subunit 8 antibody
see all
Database links
- Entrez Gene: 286885 Cow
- Entrez Gene: 27089 Human
- Entrez Gene: 22272 Mouse
- Entrez Gene: 497902 Rat
- Omim: 612080 Human
- SwissProt: P13271 Cow
- SwissProt: O14949 Human
- SwissProt: Q9CQ69 Mouse
see all
Anti-UQCRQ antibody [1H9DE5DG5BC8] images:
Western blot - testtesttest antibody [1H9DE5DG5BC8] (ab110255)
All lanes : Anti-UQCRQ antibody [1H9DE5DG5BC8] (ab110255) at 1 µg/ml
Lane 1 : Human mitochondrial lysate at 10 µg
Lane 2 : Cow mitochondrial lysate at 1 µg
Lane 3 : Rat mitochondrial lysate at 10 µg
Lane 4 : Mouse mitochondrial lysate at 10 µg
Predicted band size : 6 kDa
References for Anti-UQCRQ antibody [1H9DE5DG5BC8] (ab110255)
This product has been referenced in:
- Mineri R et al. How do human cells react to the absence of mitochondrial DNA? PLoS One 4:e5713 (2009).Read more (PubMed: 19492094) »
- Fernandez-Vizarra E et al. Impaired complex III assembly associated with BCS1L gene mutations in isolated mitochondrial encephalopathy. Hum Mol Genet 16:1241-52 (2007).Read more (PubMed: 17403714) »
See all 3 publications for this product
Publishing research using ab110255? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"