Overview

  • Product nameURB 597
  • Description
    Potent and selective FAAH inhibitor
  • Biological descriptionPotent and selective fatty acid amide hydrolase (FAAH) inhibitor (IC50 values are 4.6 nM in brain membranes and 0.5 nM in neurons respectively). Causes accumulation of anandamide. Displays anxiolytic, anti-depressant, anti-nociceptive and analgesic effect.
  • Purity> 98%
  • General notes

    This compound has been found to be unstable in DMSO even at room temperature.

Properties

    References for URB 597 (ab120668)

    This product has been referenced in:
    • Hasanein P  et al. URB597, an inhibitor of fatty acid amide hydrolase, reduces hyperalgesia in diabetic rats. Can J Physiol Pharmacol 87:432-9 (2009). Read more (PubMed: 19526037) »
    • Russo R  et al. The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice. J Pharmacol Exp Ther 322:236-42 (2007). Read more (PubMed: 17412883) »
    • Kathuria S  et al. Modulation of anxiety through blockade of anandamide hydrolysis. Nat Med 9:76-81 (2003). Read more (PubMed: 12461523) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"