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Overview

  • Product nameUSP20 peptide (901-913)See all USP20 proteins and peptides ...
  • Protein descriptionSynthetic peptide: C-HGEQKIEAETRAV, corresponding to amino acids 901-913 of Human USP20.

    • Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Concentration information loading...
  • SequenceC-HGEQKIEAETRAV
  • Research Areas

    • Applications

  • Application notesThis peptide can be used with studies using ab5272.

    • Protein info

    • Alternative names
        Deubiquitinating enzyme 20hVDU2KIAA1003
        LSFR 3ALSFR3ApVHL interacting deubiquitinating enzyme 2Ubiquitin carboxyl terminal hydrolase 20Ubiquitin carboxyl-terminal hydrolase 20ubiquitin specific peptidase 20Ubiquitin specific processing protease 20Ubiquitin specific protease 20Ubiquitin thioesterase 20Ubiquitin thiolesterase 20Ubiquitin-specific-processing protease 20UBP20_HUMANUSP 20USP20VDU 2VDU2VHL interacting deubiquitinating enzyme 2VHL-interacting deubiquitinating enzyme 2
      see all
  • FunctionDeubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
  • Sequence similaritiesBelongs to the peptidase C19 family. USP20/USP33 subfamily.
    Contains 2 DUSP domains.
    Contains 1 UBP-type zinc finger.
  • DomainThe UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conserved Arg in position 55 is replaced by a Glu residue.
  • Post-translational
    modifications    Ubiquitinated via a VHL-dependent pathway for proteasomal degradation.
  • Cellular localizationCytoplasm > perinuclear region. According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.

    • Target information above from: UniProt accession Q9Y2K6 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for USP20 peptide (901-913) (ab23089)

    ab23089 has not yet been referenced specifically in any publications.

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