You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Overview

  • Product nameUSP6 peptide (773-786)See all USP6 proteins and peptides ...
  • Protein descriptionSynthetic peptide: KISPLHHLQMECSP, corresponding to amino acids 773-786 of Human USP6.

    • Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Concentration information loading...
  • SequenceKISPLHHLQMECSP
  • Research Areas

    • Applications

  • Application notesThis peptide can be used with studies using ab4553.

    • Protein info

    • Alternative names
        Deubiquitinating enzyme 6HRP1Hyperpolymorphic gene 1
        Proto-oncogene TRE-2TRE 2 oncogeneTRE17TRE2Ubiquitin carboxyl-terminal hydrolase 6Ubiquitin Specific Protease 6Ubiquitin specific protease 6Ubiquitin thiolesterase 6Ubiquitin-specific-processing protease 6UBP6_HUMANUSP6
      see all
  • FunctionDeubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.
  • Tissue specificityTestis specific. Expressed in various cancer cell lines.
  • Involvement in diseaseNote=A chromosomal aberration involving USP6 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with CDH11. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.
  • Sequence similaritiesBelongs to the peptidase C19 family.
    Contains 1 Rab-GAP TBC domain.
  • DomainThe Rab-GAP TBC domain lacks GTPase activator activity but is necessary for interaction with ARF6.
  • Post-translational
    modifications    Monubiquitinated; ubiquitination is calmodulin and calcium dependent.
  • Cellular localizationCell membrane. Cytoplasm. Endosome. Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton.

    • Target information above from: UniProt accession P35125 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for USP6 peptide (773-786) (ab23054)

    ab23054 has not yet been referenced specifically in any publications.

    Publishing research using ab23054 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit an Abreview for ab23054 Submit a Question for ab23054

    There are currently no Abreviews or Questions for ab23054.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"