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Overview

  • Product nameUrokinase protein (Human)See all Urokinase proteins and peptides ...
  • Protein descriptionRecombinant full length Human Urokinase produced in insect cell culture as the two-chain form; MWt 54kDa (UniProt P00749).
  • Expression hostInsect cells

    • Properties

  • Purification notes> 98% pure by SDS PAGE.
  • Biological activityab92767 is fully complexable with Human PAI-1.
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 0.1M Sodium chloride, 0.05M Sodium acetate, 1mM EDTA, pH 5.0
  • Concentration information loading...
  • Additional notesSolubility: > 2 mg/mL
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab92767 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE
    Functional Studies
  • Application notesFuncS: Use at an assay dependent dilution. For plasminogen activation and receptor binding studies.
    SDS-PAGE: Use at an assay dependent dilution.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        ATFATF uPABDPLT5
        OTTHUMP00000019849Plasminogen activatorPlasminogen activator urinaryPlasminogen activator urokinasePLAUQPDu PAU plasminogen activatoru-PAU-plasminogen activatorUPAURKUROK_HUMANUrokinase plasminogen activatorUrokinase type plasminogen activatorUrokinase type plasminogen activator precursorUrokinase-type plasminogen activator chain B
      see all
  • FunctionSpecifically cleave the zymogen plasminogen to form the active enzyme plasmin.
  • Tissue specificityExpressed in the prostate gland and prostate cancers.
  • Sequence similaritiesBelongs to the peptidase S1 family.
    Contains 1 EGF-like domain.
    Contains 1 kringle domain.
    Contains 1 peptidase S1 domain.
  • Post-translational
    modifications    Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession P00749 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    Urokinase protein (Human) images

    • SDS-PAGE - Urokinase protein (Human) (ab92767)
      SDS-PAGE - Urokinase protein (Human) (ab92767)
      10% SDS-PAGE analysis of ab92767:
      Lane 1. 3ug ab92767 non reduced
      Lane 2. 3ug ab92767 + 12ug PAI-1 non reduced
      Lane 3. Prestained standard

    References for Urokinase protein (Human) (ab92767)

    ab92767 has not yet been referenced specifically in any publications.

    Publishing research using ab92767 ? Please let us know so that we can cite the reference in this datasheet

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