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SDS-PAGE - VAMP1 protein (ab63841)
(enlarge)
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Product Name
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VAMP1 protein
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Product type
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Proteins and Peptides
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Peptide
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Recombinant fragment, corresponding to amino acids 1-91 of Human VAMP1 with an N terminal His tag.
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Tested applications
(see key)
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SDS-PAGE
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Application notes
(see key)
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Recommended dilutions
SDS-PAGE: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Neuroscience >> Cell Type Marker >> Neuron marker >> Synapse marker
Signal Transduction >> Protein Trafficking >> Vesicle Transport >> SNAPs & SNAREs
Neuroscience >> Neurotransmission >> Secretory Vesicles >> Other
Neuroscience >> Neurotransmission >> Secretory Vesicles >> SNAPs & SNAREs
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Relevance
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The Vesicle Associated Membrane Proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer's disease, VAMP levels of all isoforms appear to be significantly lowered. It has been shown that the extreme carboxy-terminus of VAMP1 is involved in subcellular vesicle targeting.
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Purity
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>95% by SDS-PAGE
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Storage buffer
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Preservative: None
Constituents: PBS, 1mM EDTA, pH 7.4
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Purification notes
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ab63841 was purified by using conventional chromatography techniques.
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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Expression system
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E. coli
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Sequence
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MGSSHHHHHH SSGLVPRGSH MSAPAQPPAE GTEGTAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIIRV NVDKVLERDQ KLSELDDRAD ALQAGASQFE SSAAKLKRKY W
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this VAMP1 protein is on this datasheet. But please do contact us if you would like any reassurance! |
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VAMP1 protein images:
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 SDS-PAGE - VAMP1 protein (ab63841)
15% SDS PAGE
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Search PubMed (MEDLINE) for references to VAMP1
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VAMP1 protein - more information
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Customer reviews (feedback) regarding VAMP1 protein |
Customer FAQs regarding VAMP1 protein |
Protocols for VAMP1 protein |
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