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Anti-VAMP2 antibody (ab18014)

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Overview

Product name

Anti-VAMP2 antibody
See all VAMP2 products (10) ...

Description

Rabbit polyclonal to VAMP2

Tested applications

IP, ICC/IF, WBmore details

Cross reactivity

Reacts with

Mouse, Rat, Guinea pig, Cow, Human, Xenopus laevis

Predicted to work with

Rabbit, Fruit fly (Drosophila melanogaster), Zebrafish, Rhesus monkey

Immunogen

Synthetic peptide: QAQVDEVVDIMRVNVDKVLER conjugated to KLH, corresponding to amino acids 36-56 of Rat VAMP2. This sequence is identical to mouse, human, and bovine over these residues.

QAQVDEVVDI MRVNVDKVLE R

Run BLAST with BLAST the sequence with ExPASyRun BLAST with BLAST the sequence with NCBI

Positive control

Rat brain tissue extract

Properties

Form

Liquid

Storage instructions

Add glycerol to a final volume of 50%, aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Whole serum

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Integration of energy metabolism
Neuroscience >> Cell Type Marker >> Neuron marker >> Synapse marker
Signal Transduction >> Protein Trafficking >> Vesicle Transport >> SNAPs & SNAREs

Applications

Show applications key

Our Abpromise guarantee covers the use of ab18014 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

ICC/IF: Use at an assay dependent dilution.
IP: Use at an assay dependent dilution (PMID 18704195).
WB: 1/1000 - 1/2000. Detects a band of approximately 18 kDa (predicted molecular weight: 13.92 kDa).

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Involved in the targeting and/or fusion of transport vesicles to their target membrane.

Tissue specificity

Nervous system and skeletal muscle.

Sequence similarities

Belongs to the synaptobrevin family.
Contains 1 v-SNARE coiled-coil homology domain.

Cellular localization

Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cell junction > synapse > synaptosome. Neuronal synaptic vesicles.

Target information above from: UniProt accessionP63027 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • FLJ11460 antibody
  • RATVAMPB antibody
  • RATVAMPIR antibody
  • SYB 2 antibody
  • SYB antibody
  • SYB2 antibody
  • Synaptobrevin 2 antibody
  • Synaptobrevin-2 antibody
  • Synaptobrevin2 antibody
  • VAMP 2 antibody
  • VAMP-2 antibody
  • Vamp2 antibody
  • VAMP2_HUMAN antibody
  • Vesicle associated membrane protein 2 antibody
  • Vesicle-associated membrane protein 2 (synaptobrevin 2) antibody
  • Vesicle-associated membrane protein 2 antibody
see all

Database links

see all

References for Anti-VAMP2 antibody (ab18014)

This product has been referenced in:

  • Han Cet al. Human SCAMP5, a novel secretory carrier membrane protein, facilitates calcium-triggered cytokine secretion by interaction with SNARE machinery. J Immunol 182:2986-96 (2009). WB; Human, Mouse.Read more (PubMed: 19234194) »
  • Amin NDet al. Cyclin-dependent kinase 5 phosphorylation of human septin SEPT5 (hCDCrel-1) modulates exocytosis. J Neurosci 28:3631-43 (2008). WB; Mouse, Rat.Read more (PubMed: 18385322) »

See all 4 publications for this product

Publishing research using ab18014? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"