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Anti-VAMP4 antibody (ab6185)

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Overview

Product name

Anti-VAMP4 antibody
See all VAMP4 products (7) ...

Description

Rabbit polyclonal to VAMP4

Specificity

Reacts specifically with 10 kD protein of human CaCo-2 cell extracts.

Tested applications

WB, IP, IFmore details

Cross reactivity

Reacts with

Human

Does not react with

Rat, Dog

Immunogen

N-terminal domain synthetic peptide (Human).

General notes

. KSH 19/10/2007 Customer reports potential cross-reactivity with rat

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Whole Serum

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Signal Transduction >> Protein Trafficking >> Golgi Proteins
Signal Transduction >> Protein Trafficking >> Vesicle Transport >> SNAPs & SNAREs

Applications

Show applications key

Our Abpromise guarantee covers the use of ab6185 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • WB

     

  • IP

     

  • IF

     

Application notes

IF: 1/50.
IP: Use at an assay dependant dilution.
WB: 1/200 - 1/2000.

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.

Sequence similarities

Belongs to the synaptobrevin family.
Contains 1 v-SNARE coiled-coil homology domain.

Cellular localization

Golgi apparatus > trans-Golgi network membrane. Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles.

Target information above from: UniProt accessionO75379 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • VAMP 24 antibody
  • VAMP 4 antibody
  • VAMP-4 antibody
  • VAMP24 antibody
  • VAMP4 antibody
  • VAMP4 protein antibody
  • VAMP4_HUMAN antibody
  • Vesicle associated membrane protein 4 antibody
  • Vesicle associated membrane protein 4 isoform CRA a antibody
  • Vesicle associated membrane protein 4 isoform CRA b antibody
  • Vesicle-associated membrane protein 4 antibody
see all

Database links

References for Anti-VAMP4 antibody (ab6185)

This product has been referenced in:

  • Lieu ZZet al. The golgin GCC88 is required for efficient retrograde transport of cargo from the early endosomes to the trans-Golgi network. Mol Biol Cell 18:4979-91 (2007). ICC/IF; Human.Read more (PubMed: 17914056) »

See 1 publication for this product

Publishing research using ab6185? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"