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Product Name
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VAMP4 antibody
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See all VAMP4 antibodies (5)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to VAMP4
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Immunogen
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N-terminal domain synthetic peptide (Human).
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Reacts with
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Hu
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Does not react with
(species key)
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Rat, Dog
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Specificity
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Reacts specifically with 10 kD protein of human CaCo-2 cell extracts.
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Tested applications
(see key)
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ICC/IF, IP, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IF: 1/50.
IP: Use at an assay dependant dilution.
WB: 1/200 - 1/2000.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Golgi Apparatus
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Research areas
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Signal Transduction >> Protein Trafficking >> Golgi Proteins
Signal Transduction >> Protein Trafficking >> Vesicle Transport >> SNAPs & SNAREs
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Relevance
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VAMP4 belongs to the synaptobrevin family and contains 1 v-SNARE coiled-coil homology domain. It is involved in the pathway that removes an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. Vamp4 may be a marker for this sorting pathway that is critical for remodeling the secretory response of the secretory granule. It may play a role in trans-Golgi network-to-endosome transport.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Whole antiserum
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Storage buffer
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Preservative: None
Constituents: Whole Serum
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Form
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Liquid
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Concentration
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Concentration not determined - why is this?
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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Notes
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KSH 19/10/2007 Customer reports potential cross-reactivity with rat
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this VAMP4 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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References for VAMP4 antibody (ab6185)
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This product has been used in:
Lieu ZZ et al. The golgin GCC88 is required for efficient retrograde transport of cargo from the early endosomes to the trans-Golgi network. Mol Biol Cell 18:4979-91 (2007). ICC/IF; Human. PubMed: 17914056
If you publish research using ab6185 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to VAMP4
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VAMP4 antibody - more information
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Customer reviews (feedback) regarding VAMP4 antibody |
Customer FAQs regarding VAMP4 antibody |
Protocols for VAMP4 antibody |
Price and availability of products related to VAMP4 antibody |
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VAMP4 antibody - related products:
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VAMP4 antibody - other tools:
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Contact Abcam with a Technical Enquiry about VAMP4 antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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