VANGL1 antibody (ab80055)

Product Name 

VANGL1 antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to VANGL1

Immunogen 

Synthetic peptide derived from the N terminal domain of Human VANGL1

Reacts with 

Hu

Predicted to react 
(species key)

Ms
(Due to sequence homology)

Tested applications 
(see key)

IHC-Fr, WB

Abreviews 

Customer reviews (see key)

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Application notes 
(see key)

Recommended dilutions
IHC-Fr: 1/100 - 1/200.
WB: 1/500 - 1/5000. Predicted molecular weight: 60 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Membrane; Multi-pass membrane protein

Research areas 

Stem Cells >> Signaling Pathways >> Wnt >> Surface Molecules
Neuroscience >> Neurology process >> Neurogenesis

Relevance 

VANGL1, or Van Gogh like protein 1, is a homologue of Drosophila Van Gogh/Strabismus. It has four transmembrane domains, which classifies it as a tetraspanin family member. VANGL1 homologues have been implicated in planar cell polarity pathway and cell fate in fly, Xenopus , and mouse.
VANGL1 is phosphorylated in response to ITF stimulation and appears to be necessary for the effects of ITF. Functionally, Vangl1 enhances wound closure of intestinal epithelial cells. Mutations in VANGL1 are associated with neural-tube defects.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Whole antiserum

Storage buffer 

Preservative: None
Constituents: Whole serum

Form 

Liquid

Concentration 

Concentration not determined - why is this?

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

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