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Products:Signal Transduction >> Protein Trafficking >> Vesicle Transport >> Regulation
Overview
Product name
Anti-VAPB antibody
See all VAPB products (4) ...
Description
Mouse polyclonal to VAPB
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide, corresponding to amino acids 1-243 of Human VAPB
Positive control
Human liver tissue lysate and VAPB transfected 293T cell lysate
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Signal Transduction >> Protein Trafficking >> Vesicle Transport >> Regulation
Applications
Show applications key
Our Abpromise guarantee covers the use of ab67062 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 2 Images
WB
Application notes
WB: 1/500 - 1/1000. Detects a band of approximately 27 kDa (predicted molecular weight: 27 kDa).
Detection pair
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
VAPB contains 1 MSP domain and it may play a role in vesicle trafficking. Defects in VAPB are a cause of proximal adult autosomal dominant spinal muscular atrophy [MIM:182980]; also called late onset spinal muscular atrophy Finkel type. Spinal muscular atrophies are neurodegenerative disorders characterized by degeneration of lower motor neurons, leading to progressive paralysis muscular atrophy. This form is a late adult onset form of the disease (after age 20 years). The patients show a benign course, most of them remaining ambulatory 10 to 40 years after clinical onset.
Cellular localization
Cell membrane; Single-pass type IV membrane. Intracytoplasmic membrane; Single-pass type IV membrane protein. Note: Present in the plasma membrane and in intracellular vesicles.
Alternative names
- ALS 8 antibody
- ALS8 antibody
- D2Abb2e antibody
see all
Database links
- Entrez Gene: 9217 Human
- Omim: 605704 Human
- SwissProt: O95292 Human
- Unigene: 182625 Human
Anti-VAPB antibody images:
Western blot - VAPB antibody (ab67062)
Anti-VAPB antibody (ab67062) at 1/500 dilution + Human liver lysate at 25 µg
Secondary
Goat anti-mouse IgG (H&L)-HRP conjugate at 1/2500 dilution
Predicted band size : 27 kDa
Observed band size : 27 kDa
Western blot - VAPB antibody (ab67062)
All lanes : Anti-VAPB antibody (ab67062) at 1/500 dilution
Lane 1 : VAPB transfected 293T cell lysate
Lane 2 : Non transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Secondary
Goat anti-mouse IgG (H&L)-HRP conjugate at 1/2500 dilution
Predicted band size : 27 kDa
Observed band size : 27 kDa
References for Anti-VAPB antibody (ab67062)
ab67062 has not yet been referenced specifically in any publications.
Publishing research using ab67062? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"