VAPB antibody (ab72470)

Product Name 

VAPB antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to VAPB

Immunogen 

A synthetic peptide from a cytoplasmic part (middle region) of VAPB conjugated to an immunogenic carrier protein. The peptide is homologous in many species including human, rat, mouse, zebrafish, cow, xenopus and chicken.

Reacts with 

Hu, Ms, Rat

Predicted to react 
(species key)

Chk, Cow, Xl, Zfsh
(Due to sequence homology)

Tested applications 
(see key)

IHC-Fr, IHC-P, WB

Abreviews 

Customer reviews (see key)

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Application notes 
(see key)

Recommended dilutions
IHC-Fr: Use at a concentration of 10 - 50 µg/ml. Antigen retrieval is recommended.
IHC-P: Use at a concentration of 10 - 50 µg/ml.
WB: Use at a concentration of 10 - 50 µg/ml. Predicted molecular weight: 27 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Cell membrane; Single pass type IV membrane. Intracytoplasmic membrane; Single pass type IV membrane protein. Note: Present in the plasma membrane and in intracellular vesicles.

Research areas 

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Signal Transduction >> Protein Trafficking >> Vesicle Transport >> Regulation

Relevance 

VAPB contains 1 MSP domain and it may play a role in vesicle trafficking.
Defects in VAPB are a cause of proximal adult autosomal dominant spinal muscular atrophy [MIM:182980]; also called late onset spinal muscular atrophy Finkel type. Spinal muscular atrophies are neurodegenerative disorders characterized by degeneration of lower motor neurons, leading to progressive paralysis muscular atrophy. This form is a late adult onset form of the disease (after age 20 years). The patients show a benign course, most of them remaining ambulatory 10 to 40 years after clinical onset.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

IgG fraction

Storage buffer 

Preservative: None
Constituents: 1X PBS

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.

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