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Products:Signal Transduction >> Protein Trafficking >> Vesicle Transport >> Regulation
Overview
Product name
Anti-VAPB antibody
See all VAPB products (4) ...
Description
Rabbit polyclonal to VAPB
Tested applications
WB, IHC-Fr, IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Rat, Human
Predicted to work with
Chicken, Cow, Xenopus laevis, Zebrafish
Immunogen
A synthetic peptide from a cytoplasmic part (middle region) of VAPB conjugated to an immunogenic carrier protein. The peptide is homologous in many species including human, rat, mouse, zebrafish, cow, xenopus and chicken.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 1X PBS
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Signal Transduction >> Protein Trafficking >> Vesicle Transport >> Regulation
Applications
Show applications key
Our Abpromise guarantee covers the use of ab72470 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
IHC-Fr
IHC-P
Application notes
IHC-Fr: Use at a concentration of 10 - 50 µg/ml. Antigen retrieval is recommended.
IHC-P: Use at a concentration of 10 - 50 µg/ml.
WB: Use at a concentration of 10 - 50 µg/ml. Predicted molecular weight: 27 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
VAPB contains 1 MSP domain and it may play a role in vesicle trafficking. Defects in VAPB are a cause of proximal adult autosomal dominant spinal muscular atrophy [MIM:182980]; also called late onset spinal muscular atrophy Finkel type. Spinal muscular atrophies are neurodegenerative disorders characterized by degeneration of lower motor neurons, leading to progressive paralysis muscular atrophy. This form is a late adult onset form of the disease (after age 20 years). The patients show a benign course, most of them remaining ambulatory 10 to 40 years after clinical onset.
Cellular localization
Cell membrane; Single-pass type IV membrane. Intracytoplasmic membrane; Single-pass type IV membrane protein. Note: Present in the plasma membrane and in intracellular vesicles.
Alternative names
- ALS 8 antibody
- ALS8 antibody
- D2Abb2e antibody
see all
Database links
- Entrez Gene: 326580 Cow
- Entrez Gene: 9217 Human
- Entrez Gene: 56491 Mouse
- Entrez Gene: 60431 Rat
- Omim: 605704 Human
- SwissProt: A2VDZ9 Cow
- SwissProt: O95292 Human
- SwissProt: Q9QY76 Mouse
see all
References for Anti-VAPB antibody (ab72470)
ab72470 has not yet been referenced specifically in any publications.
Publishing research using ab72470? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"