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Products:Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Small G Proteins >> Regulators
Overview
Product name
Anti-VAV1 antibody
See all VAV1 products (6) ...
Description
Rabbit polyclonal to VAV1
Specificity
This antibody detects endogenous levels of total VAV1 protein.
Tested applications
ELISA, ICC/IFmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
A synthesized non-phosphopeptide derived from human VAV1 around the phosphorylation site of tyrosine 160
Positive control
Hela cells
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS, 150mM Sodium chloride, pH 7.4
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Signal transduction >> G protein signaling >> Small G proteins >> Other
Epigenetics and Nuclear Signaling >> Transcription >> Cancer susceptibility >> Proto-oncogenes
Cell Biology >> Cell Cycle >> Cell differentiation
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Small G Proteins >> Regulators
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Immunocytochemistry/ Immunofluorescence - VAV1 antibody (ab62622)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab62622 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
ELISA: 1/5000ELISA: 1/5000
ICC/IF: 1/500 - 1/1000.
Target
Function
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
Tissue specificity
Widely expressed in hematopoietic cells but not in other cell types.
Sequence similarities
Contains 1 CH (calponin-homology) domain.
Contains 1 DH (DBL-homology) domain.
Contains 1 PH domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 SH2 domain.
Contains 2 SH3 domains.
Domain
The DH domain is involved in interaction with CCPG1.
Post-translational
modifications
Phosphorylated on tyrosine residues.
Target information above from: UniProt accessionP15498
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Oncogene vav antibody
- p95Vav antibody
- Proto oncogene vav antibody
see all
Database links
- Entrez Gene: 7409 Human
- Entrez Gene: 22324 Mouse
- Omim: 164875 Human
- SwissProt: P15498 Human
- SwissProt: P27870 Mouse
- Unigene: 116237 Human
- Unigene: 248172 Mouse
Anti-VAV1 antibody images:
Immunocytochemistry/ Immunofluorescence - VAV1 antibody (ab62622)
Immunofluorescence analysis of HeLa cells, using ab62622 at a 1:500 dilution.
Left image untreated.
Right image treated with peptide.
References for Anti-VAV1 antibody (ab62622)
ab62622 has not yet been referenced specifically in any publications.
Publishing research using ab62622? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"