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Anti-VAV2 antibody [MAC 410] (ab50613)

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Overview

Product name

Anti-VAV2 antibody [MAC 410]
See all VAV2 products (10) ...

Description

Rat monoclonal [MAC 410] to VAV2

Specificity

Doesn't cross react with Vav-1

Tested applications

IP, WBmore details

Cross reactivity

Reacts with

Mouse, Rat, Human

Immunogen

Recombinant fusion protein, corresponding to amino acids 552-868 of Mouse VAV2

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.1% Sodium Azide
Constituents: PBS

Concentration

Concentration information loading...

Purity

Protein G purified

Clonality

Monoclonal

Clone number

MAC 410

Isotype

IgG2a

Research areas

Cancer >> Signal transduction >> G protein signaling >> Small G proteins >> Other
Epigenetics and Nuclear Signaling >> Transcription >> Cancer susceptibility >> Proto-oncogenes
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Small G Proteins >> Other

Applications

Show applications key

Our Abpromise guarantee covers the use of ab50613 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    IP

     IP: Use at an assay depe...Read more →

    IP: Use at an assay dependent dilution.

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    WB

     WB: Use at an assay depe...Read more →

    WB: Use at an assay dependent dilution. Predicted molecular weight: 101 kDa.

Target

Relevance

VAV2 is a ubiquitously expressed structural homolog of the VAV protooncogene that is expressed preferentially in hematopoetic cells. Both proteins are comprised of a Dbl homology (DH) domain with guanosine nucleotide exchange (GEF) activity exclusively directed towards Rho/Rac GTPases, a pleckstrin homology (PH) domain, a calponin-homology (CH) region, an acidic domain (AD) a zinc finger butterfly motif, two SH3 regions and one SH2 domain. GEF activity of RhoA family G proteins is induced by tyrosine phosphorylation in wild type VAV2, and is constitutively activated in N terminus deleted oncogene forms. Constitutive expression of a VAV2 oncoprotein may result in morphological alterations including highly enlarged cells in which karyokinesis and cytokinesis frequently are uncoupled.

Cellular localization

Cytoplasmic

Alternative names

  • Oncogene VAV2 antibody
  • Protein vav 2 antibody
  • VAV 2 antibody
  • Vav 2 oncogene antibody
  • VAV2 oncogene antibody
see all

Database links

References for Anti-VAV2 antibody [MAC 410] (ab50613)

This product has been referenced in:

See all 2 publications for this product

Publishing research using ab50613? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"