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Product Name
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VAV2 antibody [MAC 411]
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See all VAV2 antibodies (10)...
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Product type
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Primary antibodies
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Description
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Rat monoclonal [MAC 411] to VAV2
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Immunogen
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Recombinant fusion protein, corresponding to amino acids 552-868 of Mouse VAV2
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Reacts with
(species key)
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Hu, Ms, Rat
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Specificity
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Does not cross react with VAV1
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Tested applications
(see key)
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IP, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IP: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 101 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cytoplasmic
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Research areas
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Cancer >> Signal transduction >> G protein signaling >> Small G proteins >> Other
Chromatin and Nuclear Signaling >> Transcription >> Cancer susceptibility >> Proto-oncogenes
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Small G Proteins >> Other
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Relevance
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VAV2 is a ubiquitously expressed structural homolog of the VAV protooncogene that is expressed preferentially in hematopoetic cells. Both proteins are comprised of a Dbl homology (DH) domain with guanosine nucleotide exchange (GEF) activity exclusively directed towards Rho/Rac GTPases, a pleckstrin homology (PH) domain, a calponin-homology (CH) region, an acidic domain (AD) a zinc finger butterfly motif, two SH3 regions and one SH2 domain. GEF activity of RhoA family G proteins is induced by tyrosine phosphorylation in wild type VAV2, and is constitutively activated in N terminus deleted oncogene forms. Constitutive expression of a VAV2 oncoprotein may result in morphological alterations including highly enlarged cells in which karyokinesis and cytokinesis frequently are uncoupled.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rat
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Clonality
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Monoclonal
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Clone number
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MAC 411
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Isotype
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IgG2a
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Purity
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Protein G purified
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Storage buffer
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Preservative: 0.1% Sodium Azide
Constituents: PBS Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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1.010 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this VAV2 antibody [MAC 411] is on this datasheet. But please do contact us if you would like any reassurance! |
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References for VAV2 antibody [MAC 411] (ab50691)
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This product has been used in:
Doody GM et al. Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes. EMBO J 19:6173-84 (2000). PubMed: 11080163
If you publish research using ab50691 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to VAV2
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VAV2 antibody [MAC 411] - more information
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