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Products:Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Small G Proteins >> Other
Overview
Product name
Anti-VAV2 antibody [MAC 411]
See all VAV2 products (10) ...
Description
Rat monoclonal [MAC 411] to VAV2
Specificity
Does not cross react with VAV1
Tested applications
WB, IPmore details
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Recombinant fusion protein, corresponding to amino acids 552-868 of Mouse VAV2
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Clone number
MAC 411
Isotype
IgG2a
Research areas
Cancer >> Signal transduction >> G protein signaling >> Small G proteins >> Other
Epigenetics and Nuclear Signaling >> Transcription >> Cancer susceptibility >> Proto-oncogenes
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Small G Proteins >> Other
Applications
Show applications key
Our Abpromise guarantee covers the use of ab50691 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use at an assay dependent dilution. Predicted molecular weight: 101 kDa.
IP: Use at an assay dependent dilution.
Target
Relevance
VAV2 is a ubiquitously expressed structural homolog of the VAV protooncogene that is expressed preferentially in hematopoetic cells. Both proteins are comprised of a Dbl homology (DH) domain with guanosine nucleotide exchange (GEF) activity exclusively directed towards Rho/Rac GTPases, a pleckstrin homology (PH) domain, a calponin-homology (CH) region, an acidic domain (AD) a zinc finger butterfly motif, two SH3 regions and one SH2 domain. GEF activity of RhoA family G proteins is induced by tyrosine phosphorylation in wild type VAV2, and is constitutively activated in N terminus deleted oncogene forms. Constitutive expression of a VAV2 oncoprotein may result in morphological alterations including highly enlarged cells in which karyokinesis and cytokinesis frequently are uncoupled.
Cellular localization
Cytoplasmic
Alternative names
- Oncogene VAV2 antibody
- Protein vav 2 antibody
- VAV 2 antibody
see all
Database links
- Entrez Gene: 7410 Human
- Entrez Gene: 22325 Mouse
- Entrez Gene: 296603 Rat
- Omim: 600428 Human
- SwissProt: P52735 Human
- SwissProt: Q60992 Mouse
References for Anti-VAV2 antibody [MAC 411] (ab50691)
This product has been referenced in:
- Doody GMet al. Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes. EMBO J 19:6173-84 (2000).Read more (PubMed: 11080163) »
See 1 publication for this product
Publishing research using ab50691? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"