VAV3 antibody (ab21208)

Product Name 

VAV3 antibody

Product type 

Primary antibodies

Description 

Goat polyclonal to VAV3

Immunogen 

Synthetic peptide: CSGEQGTLKLPEK (Human).
BLAST 'CSGEQGTLKLPEK' with or

Reacts with 
(species key)

Hu

Tested applications 
(see key)

ELISA, IHC-P, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
ELISA: 1/64000.
IHC-P: 1/200 (See PMID 19008376).
WB: Use at a concentration of 1 - 3 µg/ml. Predicted molecular weight: 90 kDa.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

Human Bone Marrow lysate.

Cellular localization 

Cell Membrane and Cytoplasmic

Research areas 

Cancer >> Signal transduction >> G protein signaling >> Small G proteins >> Other
Cancer >> Cell cycle >> Cell division
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Small G Proteins >> Regulators

Relevance 

Vav proteins are members of the Dbl-family of GEFs (Guanine Nucleotide Exchange Factors) for the Rho/Rac-family GTPases which activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. Vav proteins play pivotal roles in cytoskeletal re-organization in processes such as cell division and adhesion, phagocytosis, and platelet activation.
At least three Vav isoforms have been identified; Vav1, Vav2 and Vav3.
VAV3 is expressed in many tissues and participates in signal transduction processes. It is involved in the activation of several members of the Rho family. This activity, when deregulated, leads to marked cytoskeletal changes and to alterations in the process of cell division. Vav3 promotes PLC and PI3 Kinase activation, thus mediating Ca2+-dependent signalling.

Database links 

Raised in 

Goat

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, Tris buffered saline. pH 7.3

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Purification notes 

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Form 

Liquid

Concentration 

0.500 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

See below for VAV3 antibody images, references, products related to ab21208 and other tools.

VAV3 antibody images:

References for VAV3 antibody (ab21208)

  This product has been used in:

Salhia B et al. The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma. Am J Pathol 173:1828-38 (2008). IHC-P; Human. PubMed: 19008376

If you publish research using ab21208 please let us know so that we can cite the reference on this datasheet.

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