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Product Name
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VAV3 peptide - phospho Y173 (phospho and non-phospho pair)
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Product type
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Proteins and Peptides
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Research areas
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Cancer >> Signal transduction >> G protein signaling >> Small G proteins >> Other
Cancer >> Cell cycle >> Cell division
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Small G Proteins >> Regulators
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Relevance
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Vav proteins are members of the Dbl-family of GEFs (Guanine Nucleotide Exchange Factors) for the Rho/Rac-family GTPases which activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. Vav proteins play pivotal roles in cytoskeletal re-organization in processes such as cell division and adhesion, phagocytosis, and platelet activation.
At least three Vav isoforms have been identified; Vav1, Vav2 and Vav3.
VAV3 is expressed in many tissues and participates in signal transduction processes. It is involved in the activation of several members of the Rho family. This activity, when deregulated, leads to marked cytoskeletal changes and to alterations in the process of cell division. Vav3 promotes PLC and PI3 Kinase activation, thus mediating Ca2+-dependent signalling.
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Alternative names VAV3 peptide - phospho Y173 (phospho and non-phospho pair) (ab5747) |
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Storage buffer
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Lyophilized powder with trifluoroacetate salt.
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Purification notes
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ab5747P - >85% by HPLC analysis (purity based on peak area).
ab5747N - >85% by HPLC analysis (purity based on peak area).
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Form
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Liquid
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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Notes
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Positive and negative control peptides for the Vav3 phospho tyrosine 173 rabbit polyclonal antibody ab4764.
Molecular Weight:
ab5747P - 1793
ab5747N - 1713
Peptide Content: 80 ± 4%
Quantity: 100µg of each peptide.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this VAV3 peptide - phospho Y173 (phospho and non-phospho pair) is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to VAV3
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