Overview
- Product nameAnti-VDAC/Porin antibodySee all VDAC/Porin primary antibodies ...
- DescriptionRabbit polyclonal to VDAC/Porin
- SpecificityThe antibody recognizes ~31 kDa VDAC/Porin from samples of human, mouse, rat, bovine, pig, and rabbit origins.
- Tested applicationsWB more details
- Species reactivityReacts with: Mouse, Rat, Rabbit, Cow, Human
- Immunogen
Synthetic peptide surrounding amino acid 189 of human VDAC
Properties
- FormLiquid
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
- Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
Constituents: 30% Glycerol, 0.5% BSA, PBS -
Concentration information loading... - PurityImmunogen affinity purified
- Clonality Polyclonal
- IsotypeIgG
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Research Areas
Applications
Our Abpromise guarantee covers the use of ab18988 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| WB | WB: Use a concentration of 0.5 - 4 µg/ml. Predicted molecular weight: 31 kDa. |
Target
- FunctionForms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
- Tissue specificityHeart, liver and skeletal muscle.
- Sequence similaritiesBelongs to the eukaryotic mitochondrial porin family.
- DomainConsists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.
- Cellular localizationMitochondrion outer membrane. Cell membrane.
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Database links
- Entrez Gene: 282119 Cow
- Entrez Gene: 7416 Human
- Entrez Gene: 7416 Human
- Entrez Gene: 7416 Human
- Entrez Gene: 7416 Human
- Entrez Gene: 22333 Mouse
- Entrez Gene: 100008751 Rabbit
- Entrez Gene: 83529 Rat
- Omim: 604492 Human
- SwissProt: P45879 Cow
- SwissProt: P21796 Human
- SwissProt: P21796 Human
- SwissProt: P21796 Human
- SwissProt: P21796 Human
- SwissProt: Q60932 Mouse
- SwissProt: Q9TT15 Rabbit
- SwissProt: Q9Z2L0 Rat
- Unigene: 519320 Human
- Unigene: 709506 Human
- Unigene: 3555 Mouse
- Unigene: 54594 Rat
see all
Target information above from: UniProt accession
P21796
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010)
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Alternative names
- N2441 antibody OMP2 antibody POR1 antibody
- hVDAC1 antibodyMGC111064 antibodyOuter mitochondrial membrane protein porin 1 antibodyPlasmalemmal porin antibodyPorin 31 HL antibodyPorin 31HL antibodyPorin 31HM antibodyVDAC 1 antibodyVDAC antibodyVDAC-1 antibodyVDAC1 antibodyVDAC1_HUMAN antibodyVoltage dependent anion channel 1 antibodyVoltage dependent anion selective channel protein 1 antibodyVoltage-dependent anion-selective channel protein 1 antibodyYNL055C antibodyYNL2441C antibody
see all
Anti-VDAC/Porin antibody images
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Western blot - VDAC/Porin antibody (ab18988)
Predicted band size : 31 kDa
References for Anti-VDAC/Porin antibody (ab18988)
ab18988 has not yet been referenced specifically in any publications.
