Anti-VDAC/Porin antibody (ab97851)

Overview

• Product nameAnti-VDAC/Porin antibodySee all VDAC/Porin primary antibodies ...
• Description
  Rabbit polyclonal to VDAC/Porin
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rabbit, Cow, Pig
• Immunogen

  Recombinant fragment, corresponding to a sequence within amino acids 1-181 of Human VDAC/Porin (AAH08482).

• Positive controlA431, H1299, HeLa and HepG2 cell lysates

Properties

• FormLiquid
• Storage instructionsStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
  Constituents: 20% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Mitochondrial markers

  • Cancer
  • Cancer Metabolism
  • Cellular metabolic process

  • Signal Transduction
  • Metabolism
  • Plasma Membrane
  • Channels

  • Signal Transduction
  • Metabolism
  • Mitochondrial

  • Tags & Cell Markers
  • Subcellular Markers
  • Organelles
  • Mitochondria

Applications

Target

• FunctionForms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
• Tissue specificityHeart, liver and skeletal muscle.
• Sequence similaritiesBelongs to the eukaryotic mitochondrial porin family.
• DomainConsists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.
• Cellular localizationMitochondrion outer membrane. Cell membrane.

Target information above from: UniProt accession P21796 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 282119 Cow
  • Entrez Gene: 7416 Human
  • Entrez Gene: 7416 Human
  • Entrez Gene: 7416 Human
  • Entrez Gene: 7416 Human
  • Entrez Gene: 22333 Mouse
  • Entrez Gene: 397010 Pig
  • Entrez Gene: 100008751 Rabbit

  • Omim: 604492 Human
  • SwissProt: P45879 Cow
  • SwissProt: P21796 Human
  • SwissProt: P21796 Human
  • SwissProt: P21796 Human
  • SwissProt: P21796 Human
  • SwissProt: Q60932 Mouse
  • SwissProt: Q9MZ16 Pig
  • SwissProt: Q9TT15 Rabbit
  • Unigene: 519320 Human
  • Unigene: 709506 Human
  • Unigene: 3555 Mouse

  see all

• Alternative names
  N2441 antibody OMP2 antibody POR1 antibody

  hVDAC1 antibodyOuter mitochondrial membrane protein porin 1 antibodyPlasmalemmal porin antibodyPorin 31HL antibodyPorin 31HM antibodyVDAC antibodyVDAC-1 antibodyVDAC1 antibodyVDAC1_HUMAN antibodyVoltage dependent anion channel 1 antibodyVoltage dependent anion selective channel protein 1 antibodyVoltage-dependent anion-selective channel protein 1 antibodyYNL055C antibodyYNL2441C antibody

  see all

Anti-VDAC/Porin antibody images

• 

  Western blot - VDAC/Porin antibody (ab97851)
  Anti-VDAC/Porin antibody (ab97851) at 1/1000 dilution + A431 whole cell lysate at 30 µg
  
  Predicted band size : 31 kDa