You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Overview

  • Product nameAnti-VDAC1 / Porin antibodySee all VDAC1 / Porin primary antibodies ...
  • Description
    Rabbit polyclonal to VDAC1 / Porin
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    15 amino acid peptide from near the N terminal of Human VDAC1 / Porin

  • Positive controlHepG2 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab85123 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/200 - 1/500. Predicted molecular weight: 31 kDa.Can be blocked with VDAC1 / Porin peptide (ab95341).

Target

  • FunctionForms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
  • Tissue specificityHeart, liver and skeletal muscle.
  • Sequence similaritiesBelongs to the eukaryotic mitochondrial porin family.
  • DomainConsists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.
  • Cellular localizationMitochondrion outer membrane. Cell membrane.

    • Target information above from: UniProt accession P21796 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        hVDAC1 antibodyOuter mitochondrial membrane protein porin 1 antibodyPlasmalemmal porin antibody
        Porin 31HL antibodyPorin 31HM antibodyPorin antibodyVDAC 1 antibodyVDAC antibodyVDAC-1 antibodyVdac1 antibodyVDAC1_HUMAN antibodyVoltage Dependent Anion Channel 1 antibodyVoltage dependent anion selective channel protein 1 antibodyVoltage-dependent anion-selective channel protein 1 antibody
      see all

    Anti-VDAC1 / Porin antibody images

    References for Anti-VDAC1 / Porin antibody (ab85123)

    ab85123 has not yet been referenced specifically in any publications.

    Publishing research using ab85123 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit an Abreview for ab85123 Submit a Question for ab85123

    There are currently no Abreviews or Questions for ab85123.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"