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Western blot - VDAC1 / Porin antibody (ab85123)
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Product Name
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VDAC1 / Porin antibody
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See all VDAC1 / Porin - Loading Control antibodies (3)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to VDAC1 / Porin
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Immunogen
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15 amino acid peptide from near the N terminal of Human VDAC1 / Porin
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Reacts with
(species key)
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Hu
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Tested applications
(see key)
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
WB: 1/200 - 1/500. Predicted molecular weight: 31 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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HepG2 cell lysate
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Cellular localization
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Outer membranes of all eukaryotic mitochondria
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Research areas
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Isotype/Loading Controls >> Loading Controls >> VDAC1 - Mitochondrial Preps
Signal Transduction >> Metabolism >> Mitochondrial
Tags & Cell Markers >> Subcellular Markers >> Organelles >> Mitochondria
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Relevance
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The Voltage-Dependent Anion Channel (VDAC or mitochondrial Porin) is an outer membrane mitochondrial protein. The VDAC protein is thought to form the major pores through which adenine nucleotides cross the outer mitochondrial membrane. VDAC has also been implicated in the formation of the mitochondrial permeability transition pore complex in apoptotic cells. This complex, formed by VDAC, adenine nucleotide translocator (ANT) and cyclophilin D (CypD) is thought to allow the mitochondria to undergo metabolic uncoupling and irreversible morphologic changes that ultimately destroy the mitochondria during apoptosis. At the mRNA level, the tissue distribution of mitochondrial transport proteins appears to be related to the dependence of each tissue on mitochondrial energy production capacity. As a general rule, these are higher in tissues like skeletal muscle and heart; in liver and pancreas expression levels differ with each protein and in placenta, lung, kidney and brain the expression is lower than in the other tissues.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Whole antiserum
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Storage buffer
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Preservative: 0.02% Sodium Azide
Constituents: Whole serum Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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Concentration not determined - why is this?
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this VDAC1 / Porin antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for VDAC1 / Porin antibody images, references, products related to ab85123 and other tools.
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VDAC1 / Porin antibody images:
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Search PubMed (MEDLINE) for references to VDAC1 / Porin
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VDAC1 / Porin antibody - more information
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Customer reviews (feedback) regarding VDAC1 / Porin antibody |
Customer FAQs regarding VDAC1 / Porin antibody |
Protocols for VDAC1 / Porin antibody |
Price and availability of products related to VDAC1 / Porin antibody |
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VDAC1 / Porin antibody - related products:
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VDAC1 / Porin antibody - other tools:
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Contact Abcam with a Technical Enquiry about VDAC1 / Porin antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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Western blot - VDAC1 / Porin antibody (ab85123)