Anti-VDAC/Porin antibody (ab10523)

Overview

• Product nameAnti-VDAC/Porin antibodySee all VDAC/Porin primary antibodies ...
• Description
  Rabbit polyclonal to VDAC/Porin
• SpecificityThe immunogen used in producing this product has considerable homology (60-70%) with the human, rat, and mouse VDAC isoforms VDAC2 and VDAC3.
• Tested applicationsDot Blot more details
• Species reactivity
  Reacts with: Rat
  Predicted to work with: Rabbit, Cow, Human
• Immunogen

  Synthetic peptide conjugated to KLH, corresponding to amino acids 152-169 of Human VDAC/Porin (VDAC1).

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Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 15mM Sodium Azide
  Constituents: PBS, pH 7.4
• Concentration information loading...
• PurityIgG fraction
• Purification notesWhole antiserum is fractionated and then further purified by ion-exchange chromatography to provide the IgG fraction of antiserum that is essentially free of other rabbit serum proteins.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Mitochondrial markers

  • Metabolism
  • Types of disease
  • Cancer

  • Cancer
  • Cancer Metabolism
  • Cellular metabolic process

  • Signal Transduction
  • Metabolism
  • Mitochondrial

  • Signal Transduction
  • Metabolism
  • Plasma Membrane
  • Channels

  • Tags & Cell Markers
  • Subcellular Markers
  • Organelles
  • Mitochondria

  • Neuroscience
  • Neurotransmission
  • Receptors / Channels
  • More Ion Channels

  • Cell Biology
  • Apoptosis
  • Mitochondrial

Applications

Target

• FunctionForms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
• Tissue specificityHeart, liver and skeletal muscle.
• Sequence similaritiesBelongs to the eukaryotic mitochondrial porin family.
• DomainConsists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.
• Cellular localizationMitochondrion outer membrane. Cell membrane.

Target information above from: UniProt accession P21796 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 282119 Cow
  • Entrez Gene: 7416 Human
  • Entrez Gene: 7416 Human
  • Entrez Gene: 7416 Human
  • Entrez Gene: 7416 Human
  • Entrez Gene: 100008751 Rabbit
  • Entrez Gene: 83529 Rat
  • Omim: 604492 Human

  • SwissProt: P45879 Cow
  • SwissProt: P21796 Human
  • SwissProt: P21796 Human
  • SwissProt: P21796 Human
  • SwissProt: P21796 Human
  • SwissProt: Q9TT15 Rabbit
  • SwissProt: Q9Z2L0 Rat
  • Unigene: 519320 Human
  • Unigene: 709506 Human
  • Unigene: 54594 Rat

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• Alternative names
  N2441 antibody OMP2 antibody POR1 antibody

  hVDAC1 antibodyOuter mitochondrial membrane protein porin 1 antibodyPlasmalemmal porin antibodyPorin 31HL antibodyPorin 31HM antibodyVDAC antibodyVDAC-1 antibodyVdac1 antibodyVDAC1_HUMAN antibodyVoltage dependent anion channel 1 antibodyVoltage dependent anion selective channel protein 1 antibodyVoltage-dependent anion-selective channel protein 1 antibodyYNL055C antibodyYNL2441C antibody

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