Anti-VEGF Receptor 1 antibody [RM0001-5F13] (ab51872)

Overview

• Product nameAnti-VEGF Receptor 1 antibody [RM0001-5F13]See all VEGF Receptor 1 primary antibodies ...
• Description
  Rat monoclonal [RM0001-5F13] to VEGF Receptor 1
• SpecificityThis antibody recognizes mouse VEGFR1 and no cross reactivity to mouse VEGF Receptor 2 or VEGF Receptor 3
• Tested applicationsIHC-P, WB more details
• Species reactivity
  Reacts with: Mouse
  
• Immunogen

  Purified VEGFR1 extracellular domain (Mouse)

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: PBS
• Concentration information loading...
• PurityProtein G purified
• Clonality Monoclonal
• Clone numberRM0001-5F13
• IsotypeIgG2a
• Research Areas
  • Metabolism
  • Pathways and Processes
  • Metabolism processes
  • Hypoxia

  • Metabolism
  • Types of disease
  • Cancer

  • Cancer
  • Invasion/microenvironment
  • Angiogenesis
  • Angiogenic growth factors

  • Cancer
  • Growth factors
  • VEGF

  • Cancer
  • Cancer Metabolism
  • Response to hypoxia

  • Cancer
  • Oncoproteins/suppressors
  • Oncoproteins
  • Growth factors

  • Signal Transduction
  • Growth Factors/Hormones
  • VEGF

  • Signal Transduction
  • Protein Phosphorylation
  • Tyrosine Kinases
  • Other

  • Cardiovascular
  • Vasculature
  • Endothelium

  • Cardiovascular
  • Angiogenesis
  • Growth Factors
  • VEGF
  • VEGF Receptors

Applications

Target

• FunctionReceptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis.
• Tissue specificityMostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. It is not expressed in tumor cell lines. Isoform sFlt1 is strongly expressed in placenta.
• Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
  Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
  Contains 1 protein kinase domain.
• Cellular localizationSecreted and Cell membrane.

Target information above from: UniProt accession P17948 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 14254 Mouse
  • SwissProt: P35969 Mouse
  • Unigene: 389712 Mouse

• Alternative names
  EC 2.7.10.1 antibodyFlt 1 antibodyFLT antibody

  Flt-1 antibodyFlt1 antibodyFms like tyrosine kinase 1 antibodyFms related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) antibodyFms related tyrosine kinase 1 antibodyFms related tyrosine kinase 1 vascular endothelial growth factor/vascular permeability factor receptor antibodyFms-like tyrosine kinase 1 antibodyFRT antibodySoluble VEGF receptor 1 14 antibodySoluble VEGFR1 variant 2 antibodySoluble VEGFR1 variant 21 antibodyTyrosine protein kinase FRT antibodyTyrosine protein kinase receptor FLT antibodyTyrosine-protein kinase FRT antibodyTyrosine-protein kinase receptor FLT antibodyVascular endothelial growth factor receptor 1 antibodyVascular endothelial growth factor receptor 1 Precursor antibodyVascular endothelial growth factor vascular permeability factor receptor antibodyVascular permeability factor receptor 1 antibodyVascular permeability factor receptor antibodyVEGFR 1 antibodyVEGFR-1 antibodyVEGFR1 antibodyVGFR1_HUMAN antibody

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Anti-VEGF Receptor 1 antibody [RM0001-5F13] images

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  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - VEGF Receptor 1 antibody [RM0001-5F13] (ab51872)

  ab51872 at 1/100 dilution, staining VEGF Receptor 1 in LPS treated mouse tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).