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Anti-VEGF Receptor 1 antibody [Y103] (ab32152)

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Overview

Product name

Anti-VEGF Receptor 1 antibody [Y103]
See all VEGF Receptor 1 products (16) ...

Description

Rabbit monoclonal [Y103] to VEGF Receptor 1

Specificity

ab32152 recognises VEGF receptor 1 and its splice isoform sFlt1.

Tested applications

WB, IHC-P, ICC/IF, IP, ELISA, IHC-P, IHC-Frmore details

Cross reactivity

Reacts with

Mouse, Rat, Human

Immunogen

Synthetic peptide corresponding to residues in N terminus of human VEGF Receptor 1

Positive control

Mouse brain tissue, A431 cells, skin cancer.

General notes

Produced under U.S. Patent No. 5,675,063.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%

Concentration

Concentration information loading...

Purity

IgG fraction

Clonality

Monoclonal

Clone number

Y103

Isotype

IgG

Research areas

Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Metabolism processes >> Hypoxia
Cancer >> Cancer Metabolism >> Response to hypoxia
Cardiovascular >> Vasculature >> Endothelium
Cancer >> Oncoproteins/suppressors >> Oncoproteins >> Growth factors
Cancer >> Invasion/microenvironment >> Angiogenesis >> Angiogenic growth factors
Cancer >> Growth factors >> VEGF
Signal Transduction >> Growth Factors/Hormones >> VEGF
Signal Transduction >> Protein Phosphorylation >> Tyrosine Kinases >> Other
Cardiovascular >> Angiogenesis >> Growth Factors >> VEGF >> VEGF Receptors

  • Western blot - VEGF Receptor 1 antibody [Y103] (ab32152)Western blot - VEGF Receptor 1 antibody [Y103] (ab32152) image (enlarge)

  • Immunocytochemistry/ Immunofluorescence - VEGF Receptor 1 antibody [Y103] (ab32152)Immunocytochemistry/ Immunofluorescence - VEGF Receptor 1 antibody [Y103] (ab32152) image (enlarge)

  • Immunohistochemistry (Paraffin-embedded sections) - VEGF Receptor 1 antibody [Y103] (ab32152)Immunohistochemistry (Paraffin-embedded sections) - VEGF Receptor 1 antibody [Y103] (ab32152) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab32152 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis.

Tissue specificity

Mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. It is not expressed in tumor cell lines. Isoform sFlt1 is strongly expressed in placenta.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.

Cellular localization

Secreted and Cell membrane.

Target information above from: UniProt accessionP17948 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • EC 2.7.10.1 antibody
  • Flt 1 antibody
  • FLT antibody
  • Flt-1 antibody
  • Flt1 antibody
  • Flt1 antibody
  • Fms like tyrosine kinase 1 antibody
  • Fms related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) antibody
  • Fms related tyrosine kinase 1 antibody
  • Fms related tyrosine kinase 1 vascular endothelial growth factor/vascular permeability factor receptor antibody
  • Fms-like tyrosine kinase 1 antibody
  • FRT antibody
  • Soluble VEGF receptor 1 14 antibody
  • Soluble VEGFR1 variant 2 antibody
  • Soluble VEGFR1 variant 21 antibody
  • Tyrosine protein kinase FRT antibody
  • Tyrosine protein kinase receptor FLT antibody
  • Tyrosine-protein kinase FRT antibody
  • Tyrosine-protein kinase receptor FLT antibody
  • Vascular endothelial growth factor receptor 1 antibody
  • Vascular endothelial growth factor receptor 1 Precursor antibody
  • Vascular endothelial growth factor vascular permeability factor receptor antibody
  • Vascular permeability factor receptor 1 antibody
  • Vascular permeability factor receptor antibody
  • VEGFR 1 antibody
  • VEGFR-1 antibody
  • VEGFR1 antibody
  • VEGFR1 antibody
  • VGFR1_HUMAN antibody
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Database links

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Anti-VEGF Receptor 1 antibody [Y103] images:

  Western blot - VEGF Receptor 1 antibody [Y103] (ab32152)

Western blot - VEGF Receptor 1 antibody [Y103] (ab32152)

Anti-VEGF Receptor 1 antibody [Y103] (ab32152) at 1/10000 dilution + mouse brain tissue

Predicted band size : 151 kDa
Observed band size : 180 kDa (why is the actual band size different from the predicted?)

  Immunocytochemistry/ Immunofluorescence - VEGF Receptor 1 antibody [Y103] (ab32152)

Immunocytochemistry/ Immunofluorescence - VEGF Receptor 1 antibody [Y103] (ab32152)

Immunofluorescent analysis of VEGF receptor 1 expression in A431 cells using 1/250 ab32152.

  Immunohistochemistry (Paraffin-embedded sections) - VEGF Receptor 1 antibody [Y103] (ab32152)

Immunohistochemistry (Paraffin-embedded sections) - VEGF Receptor 1 antibody [Y103] (ab32152)

Immunohistochemical analysis of VEGF receptor 1 expression in paraffin-embedded skin cancer, using 1/250 ab32152.

  Immunocytochemistry/ Immunofluorescence - VEGF Receptor 1 antibody [Y103] (ab32152)

Immunocytochemistry/ Immunofluorescence - VEGF Receptor 1 antibody [Y103] (ab32152)

ab32152 at 1/200 dilution staining VEGF Receptor 1 in human 293FT cells by Immunocytochemistry/ Immunofluorescence. Cells were fixed in formaldehyde and blocked in 5% BSA for 1 hour at 25°C. The primary antibody was used at 1/200 dilution in PBS and incubated with sample at 4°C for 12 hours. An Alexa Fluor® 488 conjugated Goat polyclonal to rabbit IgG was used as secondary at 1/500 dilution.

This image is courtesy of an anonymous Abreview.

See Abreview

References for Anti-VEGF Receptor 1 antibody [Y103] (ab32152)

This product has been referenced in:

  • Chen Q  et al. Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors. Biomaterials 33:4722-30 (2012).Read more (PubMed: 22444644) »
  • Pathi SS  et al. GT-094, a NO-NSAID, Inhibits Colon Cancer Cell Growth by Activation of a Reactive Oxygen Species-MicroRNA-27a: ZBTB10-Specificity Protein Pathway. Mol Cancer Res 9:195-202 (2011).Read more (PubMed: 21156786) »

See all 11 publications for this product

Publishing research using ab32152? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"