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Overview

  • Product nameVEGF Receptor 1 protein (Active)See all VEGF Receptor 1 proteins and peptides ...
  • Protein descriptionRecombinant fragment, corresponding to amino acids 784-1338 of human VEGF Receptor 1 with N-terminal proprietary tag expressed in a Baculovirus infected Sf9 cell expression system, 94kDa. Swiss ID = P17948.
  • Expression hostInsect cells

    • Properties

  • Purification notesPurity was determined to be >80% by densitometry.
  • Biological activityThe Specific activity of ab84771 was determined to be 35 nmol/min/mg.
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.This product is an active protein and may elicit a biological response in vivo, handle with caution.
  • Storage bufferPreservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab84771 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB
    Functional Studies
    SDS-PAGE
  • Application notesKinase Assay: Use at an assay dependent dilution.
    SDS-PAGE: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        EC 2.7.10.1FLTFLT 1
        Flt-1FLT1Fms like tyrosine kinase 1Fms related tyrosine kinase 1Fms related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)Fms related tyrosine kinase 1 vascular endothelial growth factor/vascular permeability factor receptorFms-like tyrosine kinase 1FRTSoluble VEGF receptor 1 14Soluble VEGFR1 variant 2Soluble VEGFR1 variant 21Tyrosine protein kinase FRTTyrosine protein kinase receptor FLTTyrosine-protein kinase FRTTyrosine-protein kinase receptor FLTVascular endothelial growth factor receptor 1Vascular endothelial growth factor vascular permeability factor receptorVascular permeability factor receptorVascular permeability factor receptor 1VEGFR 1VEGFR-1VEGFR1VGFR1_HUMAN
      see all
  • FunctionReceptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis.
  • Tissue specificityMostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. It is not expressed in tumor cell lines. Isoform sFlt1 is strongly expressed in placenta.
  • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • Cellular localizationSecreted and Cell membrane.

    • Target information above from: UniProt accession P17948 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    VEGF Receptor 1 protein (Active) images

    • Functional Studies - VEGF Receptor 1 protein (Active) (ab84771)
      Functional Studies - VEGF Receptor 1 protein (Active) (ab84771)
      The Specific activity of ab84771 was determined to be 35 nmol/min/mg.
    • SDS-PAGE - VEGF Receptor 1 protein (Active) (ab84771)
      SDS-PAGE - VEGF Receptor 1 protein (Active) (ab84771)
      SDS-PAGE showing ab84771 at approximately 94kDa.

    References for VEGF Receptor 1 protein (Active) (ab84771)

    ab84771 has not yet been referenced specifically in any publications.

    Publishing research using ab84771 ? Please let us know so that we can cite the reference in this datasheet

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