Overview
Product nameVEGFA proteinSee all VEGFA proteins and peptides ...
Protein descriptionRecombinant full length Mature Horse VEGFA (amino acids 27-190); 164 amino acids; predicted MWt 19.2 kDa. (UniProt Q9GKR0).
Uniprot accessionQ9GKR0
Molecular weight19.200kDa
Protein length164 amino acids
Expression hostYeast
Properties
Purification notes>95% as visualized by SDS-PAGE analysis.
FormLyophilised:Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage bufferConstituents: 90% PBS, 10% Trehalose
Concentration information loading...
Sequence notesAPMAEGEHKT HEVVKFMDVY QRSYCRPIET LVDIFQEYPD EIEYIFKPSC VPLMRCGGCC NDEGLECVPT AEFNITMQIM RIKPHQSQHI GEMSFLQHSK CECRPKKDKA RQENPCGPCS ERRKHLFVQD PQTCKCSCKN TDSRCKARQL ELNERTCRCD KPRR
Research Areas
Applications
Our Abpromise guarantee covers the use of
ab117230
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Application
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Notes |
| SDS-PAGE |
SDS-PAGE: Use at an assay dependent concentration. |
Protein info
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Alternative names
MGC70609MVCD1vascular endothelial growth factor
Vascular endothelial growth factor AVascular permeability factorVegfVEGF AVEGF-AVEGF120VegfaVEGFA_HUMANVPF
see all
FunctionGrowth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
Tissue specificityIsoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed.
Involvement in diseaseDefects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1) [MIM:603933]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
Sequence similaritiesBelongs to the PDGF/VEGF growth factor family.
Cellular localizationSecreted. VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.
References for VEGFA protein (ab117230)
ab117230
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
