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Overview

  • Product nameVEGFB protein (Active)See all VEGFB proteins and peptides ...
  • Protein descriptionRecombinant Human full-length mature VEGFB, amino acids 22-207, fused to a 20 amino acid His Tag at N-terminus, predicted MW: 21.6 kDa inclusive of tag. UniProt P49765
  • Uniprot accessionP49765
  • Molecular weight21.600kDa inclusive of tags
  • Protein length186 amino acids
  • Expression hostE. coli

    • Properties

  • Purity> 90 % by SDS-PAGE
  • Purification notesab116402 was purified by proprietary chromatographic techniques and filter sterilized.
  • Biological activityMeasured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblast. The ED50 for this effect is < 1ng/ml corresponding to a specific activity of less than 1,000,000 units/mg.
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.This product is an active protein and may elicit a biological response in vivo, handle with caution.
  • Storage bufferpH: 7.50
    Constituents: 10% Glycerol, 0.32% Tris HCl
  • Concentration information loading...
  • Sequence notesMGSSHHHHHH SSGLVPRGSH MPVSQPDAPG HQRKVVSWID VYTRATCQPR EVVVPLTVEL MGTVAKQLVP SCVTVQRCGG CCPDDGLECV PTGQHQVRMQ ILMIRYPSSQ LGEMSLEEHS QCECRPKKKD SAVKPDRAAT PHHRPQPRSV PGWDSAPGAP SPADITHPTP APGPSAHAAP STTSALTPGP AAAAADAAAS SVAKGGA.
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab116402 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent concentration.
    Functional Studies FuncS: Use at an assay dependent concentration.

    Protein info

    • Alternative names
        Vascular endothelial growth factor BVEGF BVEGF related factor
        VEGF-BVEGF-related factorVegfbVEGFB_HUMANVEGFLVRF
      see all
  • FunctionGrowth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
  • Tissue specificityExpressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.
  • Sequence similaritiesBelongs to the PDGF/VEGF growth factor family.
  • Post-translational
    modifications    VEGF-B186 is O-glycosylated.
  • Cellular localizationSecreted. Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.

    • Target information above from: UniProt accession P49765 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for VEGFB protein (Active) (ab116402)

    ab116402 has not yet been referenced specifically in any publications.

    Publishing research using ab116402 ? Please let us know so that we can cite the reference in this datasheet

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