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Read our guarantee »Products:Cardiovascular >> Angiogenesis >> Growth Factors >> VEGF >> VEGF
Anti-VEGFC antibody
See all VEGFC products (5) ...
Goat polyclonal to VEGFC
IHC-P, WB, IHC-Frmore details
Reacts with
Human
Recombinant full length protein (Human)
Liquid
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.02% Thimerosal (merthiolate)
Constituents: 50% Glycerol, 1% BSA, PBS
Concentration information loading...
Immunogen affinity purified
Polyclonal
IgG
Cancer >> Invasion/microenvironment >> Angiogenesis >> Angiogenic growth factors
Cancer >> Growth factors >> VEGF
Neuroscience >> Neurology process >> Neurogenesis
Signal Transduction >> Growth Factors/Hormones >> VEGF
Cardiovascular >> Angiogenesis >> Growth Factors >> VEGF >> VEGF
Our Abpromise guarantee covers the use of ab18883 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: Use a concentration of 15 - 25 µg/ml.
WB: Use a concentration of 0.5 - 1 µg/ml.Predicted molecular weight: 47 kDa.
IHC-Fr: Use a concentration of 15 - 25 µg/ml.
Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte.
Belongs to the PDGF/VEGF growth factor family.
Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing an heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
Secreted.
Target information above from: UniProt accessionP49767
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
ab18883 has not yet been referenced specifically in any publications.
Publishing research using ab18883? Please let us know so that we can cite the reference in this datasheet
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