VEGFC antibody (ab9546)

Product Name 

VEGFC antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to VEGFC

Immunogen 

Highly pure recombinant full length dNdC-VEGF-C protein (Rat).

Reacts with 
(species key)

Hu, Ms, Rat

Tested applications 
(see key)

ELISA, IHC-P, IP, WB

Abreviews 

Customer reviews (see key)

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Application notes 
(see key)

Recommended dilutions
ELISA: Use at a concentration of 2.5 µg/ml. Allows the detection of 0.5- 1.0 ng/well of recombinant rat VEGF-C.
IHC-P: Use at an assay dependent dilution (PMID 19412173).
IP: Use at a concentration of 1 - 10 µg/ml IgG per 1ml lysate or reaction volume.
WB: Use at a concentration of 1 µg/ml.

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Secreted

Research areas 

Cancer >> Invasion/microenvironment >> Angiogenesis >> Angiogenic growth factors
Cancer >> Growth factors >> VEGF
Neuroscience >> Neurology process >> Neurogenesis
Signal Transduction >> Growth Factors/Hormones >> VEGF
Cardiovascular >> Angiogenesis >> Growth Factors >> VEGF >> VEGF

Relevance 

Vascular endothelial growth factors (VEGFs), also known as vasculotropins, are a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGFs stimulate the proliferation of endothelial cells, induce angiogenesis, promote cell migration, increase vascular permeability, and inhibit apoptosis. The mitogenic activity of VEGFs appears to be mediated by specific VEGF receptors. The target cell specificity of VEGF is restricted to vascular endothelial cells. Vascular Endothelial Growth Factor C (VEGFC) is a member of the VEGF subfamily of PDGF-related growth factors. It is the ligand for Flt4 (VEGFR3) and KDR (VEGFR2). VEGFC binds Flt4 and induces tyrosine autophosphorylation of VEGFR3 and VEGFR2. VEGFC also stimulates the migration of bovine capillary endothelial cells in collagen gel. It is a specific growth factor for the lymphatic vascular system and mediates lymphangiogenesis. VEGFC is abundantly expressed in heart and skeletal muscle. Other tissues such as lung and kidney also express VEGFC.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Protein A purified

Storage buffer 

Preservative: None
Constituents: PBS, pH 7.4

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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VEGFC antibody images:

References for VEGFC antibody (ab9546)

  This product has been used in: (two most recent references)

Machnik A et al. Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat Med 15:545-52 (2009). IHC-P; Rat. PubMed: 19412173

Kajiya K et al. Vascular endothelial growth factor-A mediates ultraviolet B-induced impairment of lymphatic vessel function. Am J Pathol 169:1496-503 (2006). PubMed: 17003502

See all 3 publication references for this product.


If you publish research using ab9546 please let us know so that we can cite the reference on this datasheet.

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