VEGFC protein (His tag) (ab52146)
Constituents: PBS, BSA
Our Abpromise guarantee covers the use of ab52146 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
As a result of glycosylation VEGFC migrates as an 18-24 kDa protein in
SDS-PAGE under reducing conditions.
Biological Activity: Measured by its ability to stimulate phosphorylation of the VEGFR-3/FLT-4 receptor in porcine aortic endothelial cells (PAE/FLT -4 cells). The ED50 for this effect is typically 150-300 ng/ml.
Inactive in the vascular permeability assay.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- Flt 4LFlt4 ligandFLT4 ligand DHM
- Flt4-LFlt4LVascular endothelial growth factor CVascular endothelial growth factor related proteinVascular endothelial growth factor-related proteinVEGF CVEGF-CVegfcVEGFC_HUMANVRP
modificationsUndergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing an heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
References for VEGFC protein (His tag) (ab52146)
ab52146 has not yet been referenced specifically in any publications.