VEGFC protein (Human) (ab51968)

Product Name 

VEGFC protein (Human)

Product type 

Proteins and Peptides

Peptide 

Recombinant Human VEGF-C

Tested applications 
(see key)

SDS-PAGE

Application notes 
(see key)

Recommended dilutions
SDS-PAGE: Use at an assay dependent dilution.

Note: Activity of VEGF-C is tested by the stimulation of VEGF-R3 phosphorylation in cells transfected with VEGF-R3. The expected ED50 is > 200 ng/ml.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Research areas 

Cancer >> Invasion/microenvironment >> Angiogenesis >> Angiogenic growth factors
Cancer >> Growth factors >> VEGF
Neuroscience >> Neurology process >> Neurogenesis
Signal Transduction >> Growth Factors/Hormones >> VEGF
Cardiovascular >> Angiogenesis >> Growth Factors >> VEGF >> VEGF

Relevance 

Vascular endothelial growth factors (VEGFs), also known as vasculotropins, are a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGFs stimulate the proliferation of endothelial cells, induce angiogenesis, promote cell migration, increase vascular permeability, and inhibit apoptosis. The mitogenic activity of VEGFs appears to be mediated by specific VEGF receptors. The target cell specificity of VEGF is restricted to vascular endothelial cells. Vascular Endothelial Growth Factor C (VEGFC) is a member of the VEGF subfamily of PDGF-related growth factors. It is the ligand for Flt4 (VEGFR3) and KDR (VEGFR2). VEGFC binds Flt4 and induces tyrosine autophosphorylation of VEGFR3 and VEGFR2. VEGFC also stimulates the migration of bovine capillary endothelial cells in collagen gel. It is a specific growth factor for the lymphatic vascular system and mediates lymphangiogenesis. VEGFC is abundantly expressed in heart and skeletal muscle. Other tissues such as lung and kidney also express VEGFC.

Recombinant VEGF-C (Vascular Endothelial Growth Factor-C) is a 125 amino acid protein that lacks the N-terminal signal peptide

Purity 

>90% by SDS-PAGE

Purification notes 

Endotoxin level is <0.1 ng per g of VEGF-C

Form 

Lyophilised
reconstitution in 0.1% acetic acid to a concentration of 0.1-1.0 mg/ml.

Storage instructions 

Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.

Expression system 

E. coli

References for VEGFC protein (Human) (ab51968)

  This product has been used in:

Argaw AT et al. IL-1beta regulates blood-brain barrier permeability via reactivation of the hypoxia-angiogenesis program. J Immunol 177:5574-84 (2006). PubMed: 17015745

If you publish research using ab51968 please let us know so that we can cite the reference on this datasheet.

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