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Product Name
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VEGFC protein
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Product type
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Proteins and Peptides
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Peptide
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Recombinant full length protein (Mouse) 18kDa
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Tested applications
(see key)
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FuncS, SDS-PAGE
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Application notes
(see key)
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Recommended dilutions
SDS-PAGE: Use at an assay dependent dilution.
Biological Activity: VEGFC will be tested by the stimulation of VEGFR3 phosphorylation in cells transfected with VEGFR3. The expected ED50 is > 200 ng/ml.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Cancer >> Invasion/microenvironment >> Angiogenesis >> Angiogenic growth factors
Cancer >> Growth factors >> VEGF
Neuroscience >> Neurology process >> Neurogenesis
Signal Transduction >> Growth Factors/Hormones >> VEGF
Cardiovascular >> Angiogenesis >> Growth Factors >> VEGF >> VEGF
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Relevance
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Vascular endothelial growth factors (VEGFs), also known as vasculotropins, are a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGFs stimulate the proliferation of endothelial cells, induce angiogenesis, promote cell migration, increase vascular permeability, and inhibit apoptosis. The mitogenic activity of VEGFs appears to be mediated by specific VEGF receptors. The target cell specificity of VEGF is restricted to vascular endothelial cells. Vascular Endothelial Growth Factor C (VEGFC) is a member of the VEGF subfamily of PDGF-related growth factors. It is the ligand for Flt4 (VEGFR3) and KDR (VEGFR2). VEGFC binds Flt4 and induces tyrosine autophosphorylation of VEGFR3 and VEGFR2. VEGFC also stimulates the migration of bovine capillary endothelial cells in collagen gel. It is a specific growth factor for the lymphatic vascular system and mediates lymphangiogenesis. VEGFC is abundantly expressed in heart and skeletal muscle. Other tissues such as lung and kidney also express VEGFC.
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Purity
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>90% by SDS-PAGE
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Storage buffer
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Preservative: None
Constituents: 0.1% Acetic acid, with 50 µg BSA per 1 µg VEGFC.
Endotoxin level is <0.1 ng per µg of VEGFC Material safety datasheet (MSDS) for this product:
Acetic Acid MSDS
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Purification notes
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>90% by SDS-PAGE analyses.
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Form
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Lyophilised
We recommend a quick spin followed by reconstitution in 0.1% acetic acid to a concentration of 0.1-1.0 mg/ml.
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Storage instructions
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Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
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Notes
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Reconstituted VEGFC should be stored in working aliquots at -80°C.
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Expression system
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E. coli
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this VEGFC protein is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to VEGFC
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VEGFC protein - more information
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Customer reviews (feedback) regarding VEGFC protein |
Customer FAQs regarding VEGFC protein |
Protocols for VEGFC protein |
Price and availability of products related to VEGFC protein |
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VEGFC protein - other tools:
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Contact Abcam with a Technical Enquiry about VEGFC protein |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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