Overview

  • Product nameAnti-VEGFD antibody
    See all VEGFD primary antibodies
  • Description
    Rabbit polyclonal to VEGFD
  • Tested applicationsIHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    VIDEEWQRTQCSPRE

    , corresponding to internal sequence amino acids 101-115 of Human VEGFD.

  • Positive control
    • SW620, Colo320, 6T-CEM or HT1080 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab95442 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200. PubMed: 23577117
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 40 kDa.

Target

  • FunctionGrowth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
  • Tissue specificityHighly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas.
  • Sequence similaritiesBelongs to the PDGF/VEGF growth factor family.
  • Post-translational
    modifications
    Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • c-fos induced growth factor antibody
    • c-fos induced growth factor (vascular endothelial growth factor D) antibody
    • c-fos-induced growth factor antibody
    • FIGF antibody
    • Vascular endothelial growth factor D antibody
    • Vascular endothelial growth factor D precursor antibody
    • VEGF D antibody
    • VEGF-D antibody
    • VEGFD antibody
    • VEGFD_HUMAN antibody
    see all

Anti-VEGFD antibody images

  • All lanes : Anti-VEGFD antibody (ab95442) at 1 µg/ml

    Lane 1 : SW620 whole cell lysate
    Lane 2 : Colo320 whole cell lysate
    Lane 3 : 6T-CEM whole cell lysate
    Lane 4 : HT1080 whole cell lysate

    Lysates/proteins at 100 µg per lane.


    Predicted band size : 40 kDa

References for Anti-VEGFD antibody (ab95442)

This product has been referenced in:
  • Laird A  et al. Differential expression of prognostic proteomic markers in primary tumour, venous tumour thrombus and metastatic renal cell cancer tissue and correlation with patient outcome. PLoS One 8:e60483 (2013). IHC-P ; Human . Read more (PubMed: 23577117) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"